Article (Scientific journals)
The clinical and economic burden of non-adherence with oral bisphosphonates in osteoporotic patients.
Hiligsmann, Mickaël; Rabenda, Véronique; Bruyère, Olivier et al.
2010In Health Policy, 96, p. 170-176
Peer reviewed
 

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Keywords :
adherence; compliance; cost-effectiveness; economic analysis; health policy
Abstract :
[en] OBJECTIVES: This study aims to estimate the clinical and economic burden of non-adherence with oral bisphosphonates in osteoporotic patients and the potential cost-effectiveness of adherence-enhancing interventions. METHODS: A validated Markov microsimulation model estimated costs and outcomes (i.e. the number of fractures and the quality-adjusted life-year (QALY)) for three adherence scenarios: no treatment, real-world adherence and full adherence over 3 years. The real-world adherence scenario employed data from a published observational study. The incremental cost per QALY gained was estimated and compared across the three adherence scenarios. RESULTS: The number of fractures prevented and the QALY gain obtained at real-world adherence levels represented only 38.2% and 40.7% of those expected with full adherence, respectively. The cost per QALY gained of real-world adherence compared with no treatment was estimated at euro10279, and full adherence was found to be cost-saving compared with real-world adherence. CONCLUSIONS: This study suggests that more than half of the potential clinical benefits from oral bisphosphonates in patients with osteoporosis are lost due to poor adherence with treatment. Depending on their cost, interventions with improved adherence to therapy have the potential to be an attractive use of resources.
Disciplines :
Special economic topics (health, labor, transportation...)
Rheumatology
Author, co-author :
Hiligsmann, Mickaël ;  Université de Liège - ULiège > HEC-Ecole de gestion : UER > Economie industrielle
Rabenda, Véronique ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Language :
English
Title :
The clinical and economic burden of non-adherence with oral bisphosphonates in osteoporotic patients.
Publication date :
2010
Journal title :
Health Policy
ISSN :
0168-8510
eISSN :
1872-6054
Publisher :
Elsevier Scientific, Limerick, Ireland
Volume :
96
Pages :
170-176
Peer reviewed :
Peer reviewed
Commentary :
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Available on ORBi :
since 03 March 2010

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