Stem cells in the adult rat spinal cord: Plasticity after injury and treadmill training exercise

[en] ABSTRACT Ependymal cells located around the central canal of the adult spinal cord are considered as a source of neural stem cells (NSCs) and represent an interesting pool of endogenous stem cells for repair strategies. Physical exercise is known to increase ependymal cell proliferation, while improving functional recovery. In this work, we further characterized those endogenous NSCs within the normal and injured adult rat spinal cord and investigated the effects of treadmill training using immunohistochemical and behavioural studies. In uninjured untrained rats, Sox-2, a NSC marker, was detected in all ependymal cells of the central canal, and also scattered throughout the parenchyma of the spinal cord. Within the lesion, Sox-2 expression increased transiently, while the number of nestin-positive ependymal cells increased with a concomitant enhancement of proliferation, as indicated by the mitotic markers Ki67 and BrdU. Exercise, which improved functional recovery and autonomous micturition, maintained nestin expression in both injured and uninjured spinal cords, with a positive correlation between locomotor recovery and the number of nestin-positive cells.

Research center :

Giga-Neurosciences - ULiège

Disciplines :

Neurosciences & behavior
Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Foret, Ariane ; Université de Liège - ULiège > Centre de recherches du cyclotron

Quertainmont, Renaud ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Botman, O.

Bouhy, D.

AMABILI, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Service d'anesthésie - réanimation

Brook, G.

Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Franzen, Rachelle ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Language :

English

Title :

Stem cells in the adult rat spinal cord: Plasticity after injury and treadmill training exercise

Publication date :

February 2010

Journal title :

Journal of Neurochemistry

ISSN :

0022-3042

eISSN :

1471-4159

Publisher :

Blackwell Science, Oxford, United Kingdom

Volume :

112

Issue :

Pages :

762-772

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

communautés européennes

Available on ORBi :

since 01 March 2010

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