Systems biology; models; transcriptomics; proteomics; data mining; bioinformatics; genomics; therapeutic; taget; neurodegeneration
Abstract :
[en] Systems biology has emerged as a major trend in biological research during the past decade. As living organisms are described in more and more detail, it aims at filling the gap between understanding basic molecular processes and complex biological systems in which new properties often emerge from the combination of these elementary processes. This approach culminates in the development of computer-based mathematical models of physiological and pathophysiological processes. We review the state of the art in dynamic modelling, with emphasis on two complementary approaches: the modelling of small systems that is mostly developed by academic teams and aims at understanding generic biological properties, and the modelling of large systems that is mostly implemented by industrial companies and aims at the generation of new therapeutic strategies. We also provide an example of such large-scale modelling applied to the identification of drug targets for neurodegeneration.
Research Center/Unit :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
Disciplines :
Genetics & genetic processes Biochemistry, biophysics & molecular biology Engineering, computing & technology: Multidisciplinary, general & others Pharmacy, pharmacology & toxicology Chemistry Human health sciences: Multidisciplinary, general & others
Author, co-author :
Vujasinovic, Todor; Helios BioSciences
Zampera, André Sinisa; Helios BioSciences
Jackers, Pascale ; Université de Liège - ULiège > Center for Analytical Research and Technology (CART)
Sanoudou, Despina; Biomedical Research Foundation of the Academy of Athens > Molecular Biology Division
Depaulis, Antoine; Université Joseph Fourier - Grenoble 1 - UJF > Institut des Neurosciences
Language :
English
Title :
In Silico Dynamic Molecular Interaction Networks for the Discovery of New Therapeutic Targets
Validated "Predictive Dynamic Models of Complex Intracellular Pathways Related to Cell Death and Survival"
Funders :
Research funds from the European Union 6th Framework Program for Research and Technological Development, “Life sciences, genomics and biotechnology for health”, VALAPODYN, contract #LSHG-CT-2006-037277
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