Article (Scientific journals)
Modélisation moléculaire de l'usambarensine, de la tubulosine et de l'émétine, alcaloïdes cytotoxiques et antiamibiens
Quetin-Leclercq, J.; Dupont, Léon; Wright, C. W. et al.
1991In Journal de Pharmacie de Belgique, 46 (2, Mar-Apr), p. 85-92
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Keywords :
usambarensine; tubulosine; emetine; conformational analysis
Abstract :
[en] The analyses of the different possible conformations of usambarensine, tubulosine and emetine, which possess interesting cytotoxic and amoebicide properties showed us that they cannot take the planar conformation proposed to explain the activity of this type of molecules on protein synthesis. Nevertheless, a common (non planar) conformation exists where the angles between the two plans containing the aromatic rings are nearly the same for the three compounds. This fact could confirm the hypothesis of a common receptor which would be slightly different in amoebae because of its higher sensitivity to usambarensine.
Disciplines :
Physics
Pharmacy, pharmacology & toxicology
Author, co-author :
Quetin-Leclercq, J.
Dupont, Léon ;  Cristallographie
Wright, C. W.
Phillipson, J. D.
Warhurst, D. C.
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
French
Title :
Modélisation moléculaire de l'usambarensine, de la tubulosine et de l'émétine, alcaloïdes cytotoxiques et antiamibiens
Alternative titles :
[en] Molecular Modelling of Usambarensine, Tubulosine and Emetine, Cytotoxic Amebicide Alkaloids
Publication date :
1991
Journal title :
Journal de Pharmacie de Belgique
ISSN :
0047-2166
Publisher :
Association Pharmaceutique Belge, Belgium
Volume :
46
Issue :
2, Mar-Apr
Pages :
85-92
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 May 2010

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