Article (Scientific journals)
High production of SPARC/osteonectin/BM-40 in mouse metastatic B16 melanoma cell lines
Kato, Y.; Frankenne, F.; Noël, Agnès et al.
2000In Pathology Oncology Research, 6 (1), p. 24-26
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Keywords :
SPARC; osteonectin; BM-40; melanoma; metastasis
Abstract :
[en] Abstract Production of SPARC/osteonectin/BM-40 was determined in mouse B16 melanoma clones BL6 and F10 (high metastatic) and F1 (low metastatic). SPARC was produced greater amount in BL6 and F10 than in F1 cells, showing a good agreement with their metastatic potentials. Moreover, SPARC production was not influenced by culture pH, even in the acidic conditions (= pH 5.9). Although tumor tissues show often low pH due to excessive amount of acidic metabolites such as lactate, most studies have been done in neutral pH. High SPARC production in the acidic medium, therefore, is thought to be an important potential for tumor invasive behaviour.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Kato, Y.
Frankenne, F.
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Sakai, N.
Nagashima, Y.
Koshika, S.
Miyazaki, K.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Language :
English
Title :
High production of SPARC/osteonectin/BM-40 in mouse metastatic B16 melanoma cell lines
Publication date :
2000
Journal title :
Pathology Oncology Research
ISSN :
1219-4956
Publisher :
W.B. Saunders, London, United Kingdom
Volume :
6
Issue :
1
Pages :
24-26
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 May 2010

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