infrared; spectroscopy; mass spectrometry; G-quadruplex; structure; conformation; DNA
Abstract :
[en] DNA oligonucleotide ions forming G-quadruplex structures were studied in the gas phase using IRMPD spectroscopy. Data interpretation on these large biomolecule ions was made using carefully chosen control experiments. The major finding is a fingerprint of hydrogen bonding in the gas phase in the guanine C6=O6 stretching mode, that allows probing the conservation of G-quartets in the gas phase. The experiments demonstrate the conservation of G-quadruplex hydrogen bonds in the human telomeric sequence d(TTAGGG)4.
Disciplines :
Chemistry
Author, co-author :
Gabelica, Valérie ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse
Rosu, Frédéric ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse
De Pauw, Edwin ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse
Lemaire, Joël; UniVersité Paris Sud, F-91405 Orsay, France > Laboratoire de Chimie Physiques - CLIO du CNRS
Gillet, Jean-Christophe; Univ. Paris 13 > Laboratoire de Physique des Lasers du CNRS
Poully, Jean-Christophe; Univ. Paris 13 > Laboratoire de Physique des Lasers du CNRS
Lecomte, Frédéric; Univ. Paris 13 > Laboratoire de Physique des Lasers du CNRS
Grégoire, Gilles; Univ. Paris 13 > Laboratoire de Physique des Lasers du CNRS
Schermann, Jean-Pierre; Univ. Paris 13 > Laboratoire de Physique des Lasers du CNRS
Desfrançois, Charles; Univ. Paris 13 > Laboratoire de Physique des Lasers du CNRS
Language :
English
Title :
Infrared Signature of DNA G-Quadruplexes in the Gas Phase
Publication date :
2008
Journal title :
Journal of the American Chemical Society
ISSN :
0002-7863
eISSN :
1520-5126
Publisher :
American Chemical Society, Washington, United States - District of Columbia
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