Stabilization and structure of telomeric and c-myc region intramolecular G-quadruplexes: The role of central cations and small planar ligands

Gabelica, Valérie; Baker, Erin Shammel; Teulade-Fichou, Marie-Paule; De Pauw, Edwin; Bowers, Michael T

doi:10.1021/ja065989p

Article (Scientific journals)

Stabilization and structure of telomeric and c-myc region intramolecular G-quadruplexes: The role of central cations and small planar ligands

Gabelica, Valérie; Baker, Erin Shammel; Teulade-Fichou, Marie-Paule et al.

2007 • In Journal of the American Chemical Society, 129 (4), p. 895-904

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DOI
10.1021/ja065989p

PubMed
17243826

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Keywords :

mass spectrometry; ion mobility; G-quadruplex; ligand; DNA; structural biology

Abstract :

[en] A promising approach for anticancer strategies is the stabilization of telomeric DNA into a G-quadruplex structure. To explore the intrinsic stabilization of folded G-quadruplexes, we combined electrospray ionization mass spectrometry, ion mobility spectrometry, and molecular modeling studies to study different DNA sequences known to form quadruplexes. Two telomeric DNA sequences of different lengths and two DNA sequences derived from the NHE III1 region of the c-myc oncogene (Pu22 and Pu27) were studied. NH4+ and the ligands PIPER, TMPyP4, and the three quinacridines MMQ1, MMQ3, and BOQ1 were complexed with the DNA sequences to determine their effect on the stability of the G-quadruplexes. Our results demonstrate that G-quadruplex intramolecular folds are stabilized by NH4+ cations and the ligands listed. Furthermore, the ligands can be classified according to their ability to stabilize the quadruplexes and end stacking is shown to be the dominant mode for ligand attachment. In all cases our solvent-free experimental observations and theoretical modeling reveal structures that are highly relevant to the solution-phase structures.

Research Center/Unit :

Giga-Systems Biology and Chemical Biology - ULiège
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology
Chemistry

Author, co-author :

Gabelica, Valérie ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse

Baker, Erin Shammel; University of California at Santa Barbara - UCSB > Department of Chemistry and Biochemistry

Teulade-Fichou, Marie-Paule; Collège de France, Paris > Laboratoire de Chimie des Interactions Moléculaires

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse

Bowers, Michael T; University of California at Santa Barbara - UCSB > Department of Chemistry and Biochemistry

Language :

English

Title :

Stabilization and structure of telomeric and c-myc region intramolecular G-quadruplexes: The role of central cations and small planar ligands

Publication date :

2007

Journal title :

Journal of the American Chemical Society

ISSN :

0002-7863

eISSN :

1520-5126

Publisher :

Amer Chemical Soc, Washington, United States - Washington

Volume :

129

Issue :

Pages :

895-904

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 29 July 2008

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