Paper published in a book (Scientific congresses and symposiums)
Serotype Distribution of clinical isolates of group B streptococci Isolated in Belgium : isolates from neonatal infection compared to isolates from infection in adult or colonization in pregnant women
MELIN, Pierrette; Keke, D.; Campo, B.et al.
2002 • In American Society of Microbiology (Ed.) Program and Abstracts of the 43rd Intersciences Conference on Antimicrobial Agents and Chemotherapy
Group B streptococci; serotype distribution; neonatal infection; Adult infection; vaginal colonization; Belgium
Abstract :
[en] Background: Group B Streptococci cause invasive disease in neonates, pregnant women and non-pregnant
adults. In the last decades capsular serotypes (type) Ia, Ib, II and III caused the majority of clinical diseases.
More recently, in North America, type V emerged as the more common type in non-pregnant adults with
invasive disease.
Methods: From January 1999 through December 2001, we received and typed a total of 334 clinically
significant strains of GBS isolated in the laboratories belonging to the Belgian network for epidemiological
surveillance. 113 were recovered from neonates blood or cerebrospinal fluid (92 early onset EOD, 21 late
onset LOD), 14 were isolated from pregnant women with severe infections and 204 were recovered from
adults with invasive disease. From the same laboratories, during the first trimester of 2002, 302 isolates
from pregnant women were also typed (max. 5 isolates /lab.)
Results: In neonatal EOD type III was the more common (41,3%) followed by II (19.6%), Ia (16.3%), Ib
(13%), V (8.7%) and IV (1.1%), whereas type III caused the majority (85.7%) of LOD cases. In adults, all
types were well represented except type IV: 20.3% Ia, 12.7% Ib, 13.1% II, 23.1% III, 2.7% IV, 19% V and
9% remained non typeable (NT). In colonized pregnant women, all types were also well represented except
type IV: 25.5% Ia, 13.3% Ib, 14.9% II, 17.7% III, 5% IV, 15.5% V and 8.1% remained NT. Type III was
more frequently the cause of EOD than a colonizing strain during pregnancy and in contrast NT isolates did
not cause EOD (P<0.001)
Conclusions: 1) Type III was still the major type in neonatal infections in Belgium. 2) Type distribution of
GBS differed by age-group of patients 3) Type V belonged to the 3 more represented types in adults 4)
Compared to colonizing GBS in pregnant women, distribution of types causing EOD was different.
Research Center/Unit :
Centre National de Référence des Streptocoques du groupe B
Disciplines :
Laboratory medicine & medical technology Immunology & infectious disease
Author, co-author :
MELIN, Pierrette ; Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
Keke, D.
Campo, B.
HAYETTE, Marie-Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
CHRISTIAENS, Geneviève ; Centre Hospitalier Universitaire de Liège - CHU > Direction médicale
De Mol, Patrick ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Language :
English
Title :
Serotype Distribution of clinical isolates of group B streptococci Isolated in Belgium : isolates from neonatal infection compared to isolates from infection in adult or colonization in pregnant women
Publication date :
September 2002
Event name :
43rd Intersciences Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Event organizer :
American Society of Microbiology
Event place :
San Diego, United States
Event date :
du 27 au 30 septembre 2002
Audience :
International
Main work title :
Program and Abstracts of the 43rd Intersciences Conference on Antimicrobial Agents and Chemotherapy
Editor :
American Society of Microbiology
Publisher :
American Society for Microbiology (ASM), Washington, United States
