Article (Scientific journals)
Internal energy and fragmentation of ions produced in electrospray sources
Gabelica, Valérie; De Pauw, Edwin
2005In Mass Spectrometry Reviews, 24 (4), p. 566-587
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Keywords :
internal energy; electrospray; soft ionization mehods; collision-induced dissociation; mass spectrometry
Abstract :
[en] This review addresses the determination of the internal energy of ions produced by electrospray ionization (ESI) sources, and the influence of the internal energy on analyte fragmentation. A control of the analyte internal energy is crucial for several applications of electrospray mass spectrometry, like structural studies, construction of reproducible and exportable spectral libraries, analysis of non-covalent complexes. Sections II and III summarize the Electrospray mechanisms and source design considerations which are relevant to the problem of internal energy, and Section IV gives an overview of the interrelationships between ion internal energy, reaction time scale, and analyte fragmentation. In these three sections we tried to make the most important theoretical elements understandable by all ESI users, and their understanding requires a minimal background in physical chemistry. We then present the different approaches used to experimentally determine the ion internal energy, as well as various attempts in modeling the internal energy uptake in electrospray sources. Finally, a tentative comparison between electrospray and other ionization sources is made. As the reader will see, although many reports appeared on the subject, the knowledge in the field of internal energy of ions produced by soft ionization sources is still scarce, because of the complexity of the system, and this is what makes this area of research so interesting. The last section presents some perspectives for future research.
Research center :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
Disciplines :
Physics
Chemistry
Author, co-author :
Gabelica, Valérie ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse
De Pauw, Edwin  ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie physique, spectrométrie de masse
Language :
English
Title :
Internal energy and fragmentation of ions produced in electrospray sources
Publication date :
2005
Journal title :
Mass Spectrometry Reviews
ISSN :
0277-7037
eISSN :
1098-2787
Publisher :
John Wiley & Sons, Inc, Hoboken, United States - New Jersey
Volume :
24
Issue :
4
Pages :
566-587
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
This is a postprint version of an article published in Mass Spectrom. Rev. (2005), 24, 566-587. © 2004 John Wiley & Sons Ltd.
Available on ORBi :
since 29 July 2008

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