[en] Strychnine is unstable under light in chloroformic solution and is partly transformed in pseudostrychnine, genostrychnine (Nb-oxy-strychnine) and chloromethostrychninium (a quaternary derivative). In other respects the curarizing activity of African Strychnos (e.g. Strychnos usambarensis) is not due to isostrychnine as erroneously written by TURKOVIC (J.Pharm Belg. 1976, 31, 277-286) but to quaternary alkaloids like C-dihydrotoxiferine, C-curarine, afrocurarine and C-calebassine (cf L.ANGENOT et al. Arch. Intern. Pharmacodyn. Ther. 1975, 215, 246-258).
Disciplines :
Pharmacy, pharmacology & toxicology Chemistry
Author, co-author :
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Bisset, Norman
Denoël, Albert
Phillipson, J.
Language :
French
Title :
A propos des transformations de la strychnine et (à propos des principes actifs) des Strychnos curarisants africains
Alternative titles :
[en] Instability of strychnine and active principles of Strychnos usambarensis
