[en] The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight untreated essential hypertensive patients. A low salt diet decreases blood pressure, vascular resistances, erythrocyte sodium, and platelet calcium, but not platelet pH. A strong positive correlation was noted between baseline platelet calcium and vascular resistances (r=0.95, P < .01). But during the salt restriction period, a negative correlation has been observed between the changes in these parameters, which casts doubt on the use of the platelet as a mode of the smooth muscle cell.
Disciplines :
Urology & nephrology
Author, co-author :
Krzesinski, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Du, Fenghe
Pequeux, Marie-Louise; Université de Liège - ULiège > Néphrologie
Rorive, Georges ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Low sodium diet in essential hypertension- Effect on blood cell ions and hemodynamic parameters
Publication date :
July 1992
Journal title :
American Journal of Hypertension
ISSN :
0895-7061
eISSN :
1941-7225
Publisher :
Elsevier Science, New York, United States - New York
Volume :
5
Pages :
661-663
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
This article is based presented at the American Society of Hypertensin's annual meeting, May 6 to 9, 1992.
Cutler J, Follmann D, Elliott P, Suh I: An overview of randomized trials of sodium reduction and blood pressure. Hypertension 1991:17(suppl 1):1-27-1-33.
Folkow B: Critical review of studies on salt and hypertension. Clin Exper Hypertens [A] 1992;A14:1-14.
Fujita T, Noda H, Ando K: Sodium susceptibility and potassium effects in young patients with borderline hypertension. Circulation 1984;69:468-476.
Sullivan J: Salt sensitivity, definition, conception, methodology, and long-term issues. Hypertension 1991;17(suppl 1):1-61-1-68.
Cooper R, Shamsi N, Katz S: Intracellular calcium and sodium in hypertensive patients. Hypertension 1987; 9:224-229.
Astarie C, David-Dufilho M, Devynck MA: Direct characterization of the Na-H-exchanger in human platelets. FEBS Lett 1990;277:235-238.
Egan B, Petrin J, Hoffmann R: NaCl induces differential changes of regional vascular reactivity in salt-sensitive versus salt-resistant men. Am J Hypertens 1991;4:924-931.
Erne P, Bolli P, Biirgisser E, Biihler F: Correlation of platelet calcium with blood pressure. N Engl J Med 1984; 310:1084-1088.
Standley P, Gangasani S, Prakash R, et al: Human platelet calcium measurements, methodological considerations and comparisons with calcium mobilization in vascular smooth muscle cells. Am J Hypertens 1991;4:546-549.
