Reference : Arguments for the presence of a Na-K ATPase pump inhibitor in the plasma of uremic an...
Scientific journals : Article
Human health sciences : Urology & nephrology
http://hdl.handle.net/2268/37647
Arguments for the presence of a Na-K ATPase pump inhibitor in the plasma of uremic and essential hypertensive patients
English
Krzesinski, Jean-Marie mailto [Université de Liège - ULiège > Département des sciences cliniques > Néphrologie >]
Godon, Jean-Pierre [Université de Liège - ULiège > Médecine Interne > Néphrologie > >]
Rorive, Georges mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
1985
Clinical and Experimental Hypertension. Part A, Theory and Practice
Marcel Dekker
Yes (verified by ORBi)
International
0730-0077
New York
NY
[en] -K pump inhibitor ; natriuretic factor ; uremia ; essential hypertension
[en] The effect of salt and/or volume depletion has been tested in 6 end-stage renal disease and 11 essential hypertensive patients (HTA) on red blood cell (RBC) ionic fluxes. Volume depletion promotes an increase in the RBC Na-K ATPase activity with, as a result, a significant decrease in intracellular sodium concentration ((Na)ic). Moreover, a factor has been found in the plasma of uremic subjects which causes natriuresis when injected in rat renal arteries. The concentration of this factor decreases during dialysis in relation to the weight loss and the increase in the RBC Na-K pump activity. In essential hypertension, the effect of a low salt diet on the blood pressure is correlated with the improvement of RBC Na-K ATPase activity. These experiments illustrate the presence of a Na-K ATPase inhibitor in the plasma of these subjects, dependent on sodium and water balance.
Professionals
http://hdl.handle.net/2268/37647

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Arguments for the presence of Na-K Clin and exper theory and practice 1985001.pdfPublisher postprint7.7 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.