Article (Scientific journals)
Molecular pathways of angiogenesis inhibition.
Tabruyn, Sébastien; Griffioen, Arjan W
2007In Biochemical and Biophysical Research Communications, 355 (1), p. 1-5
Peer reviewed
 

Files


Full Text
BBRC.pdf
Publisher postprint (131.53 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Angiogenesis Inhibitors/therapeutic use; Angiostatins/therapeutic use; Apoptosis/drug effects; Autoantigens/therapeutic use; Cell Cycle/drug effects; Cell Division/drug effects; Cell Survival/drug effects; Collagen Type IV/therapeutic use; Endostatins/therapeutic use; Humans; Matrix Metalloproteinase 2/antagonists & inhibitors; Neovascularization, Pathologic/prevention & control; Platelet Factor 4/therapeutic use; Thrombospondin 1/therapeutic use
Abstract :
[en] A large body of evidence now demonstrates that angiostatic therapy represents a promising way to fight cancer. This research recently resulted in the approval of the first angiostatic agent for clinical treatment of cancer. Progress has been achieved in decrypting the cellular signaling in endothelial cells induced by angiostatic agents. These agents predominantly interfere with the molecular pathways involved in migration, proliferation and endothelial cell survival. In the current review, these pathways are discussed. A thorough understanding of the mechanism of action of angiostatic agents is required to develop efficient anti-tumor therapies.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Tabruyn, Sébastien ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Griffioen, Arjan W
Language :
English
Title :
Molecular pathways of angiogenesis inhibition.
Publication date :
2007
Journal title :
Biochemical and Biophysical Research Communications
ISSN :
0006-291X
eISSN :
1090-2104
Publisher :
Academic Press, San Diego, United States - California
Volume :
355
Issue :
1
Pages :
1-5
Peer reviewed :
Peer reviewed
Available on ORBi :
since 26 November 2010

Statistics


Number of views
67 (8 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
91
Scopus citations®
without self-citations
86
OpenCitations
 
68

Bibliography


Similar publications



Contact ORBi