Reference : Strychnopentamine, a Potential Anticancer Agent
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Strychnopentamine, a Potential Anticancer Agent
Quetin-Leclercq, J. [> > > >]
Bouzahzah, B. [> > > >]
Pons, A. [> > > >]
Greimers, Roland mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Bassleer, Roger [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Barbason, Hervé [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Planta Medica
Yes (verified by ORBi)
[en] strychnopentamine ; indole alkaloid ; Strychnos usambarensis ; anticancer activity ; Ehrlich ascites tumor
[en] We analysed the effects of strychnopentamine, an alkaloid isolated from Strychnos usambarensis, on an Ehrlich ascites tumor growing in the mouse after inoculation. Four subcutaneous injections of 1.5 mg strychnopentamine (1 per day) induce a significant decrease of the number of tumor cells and a significant increase of the survival of the treated mice. Observed side effects are partial haemolysis and some liver damage.

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Planta Med 59 1993 pp 59_62.pdfPublisher postprint259.64 kBRequest copy

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