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06 January 2009
Article (Scientific journals)
Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization
Jérôme, Christine  ; Lecomte, Philippe 
2008 • In Advanced Drug Delivery Reviews, 60 (9), p. 1056-1076
Peer Reviewed verified by ORBi
 

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Keywords :
lactone; ring-opening polymerization; review
Abstract :
[en] Advanced drug delivery systems rely on the availability of biocompatible materials. Moreover, biodegradability is highly desirable in the design of those systems. Consequently, aliphatic polyesters appear as a class of promising materials since they combine both properties. Nevertheless, their use in practical biomedical systems relies on clinical approval which not only depends on the material itself but also on its reproducible synthesis with the absence of residual toxics. The first sections of this review aim at reporting on the evolution of the initiators/catalytic systems and of the synthesis conditions (particularly the use of supercritical CO2 as polymerization medium) in order to produce aliphatic polyesters with controlled macromolecular parameters by still "greener" ways. In addition, the further development of delivery systems also depends on the synthesis of materials exhibiting novel properties, such as amphiphilicity or pH-sensitivity that are emerging from the active research in macromolecular engineering. Functionalizing aliphatic polyesters is quite tedious due to their sensitivity towards hydrolytic degradation. The last section of this review is discussing several strategies to obtain functional (co)polyesters of various architectures providing them with novel properties.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Jérôme, Christine ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lecomte, Philippe  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization
Publication date :
10 June 2008
Journal title :
Advanced Drug Delivery Reviews
ISSN :
0169-409X
eISSN :
1872-8294
Publisher :
Elsevier Science, Amsterdam, Netherlands
Special issue title :
Design and development strategies of polymer materials for drug and gene delivery applications
Volume :
60
Issue :
9
Pages :
1056-1076
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Commentary :
The authors acknowledge Advanced Drug Delivery Reviews (Elsevier) for allowing them to archive this paper.

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