Impact of mitral regurgitation and myocardial viability on left ventricular reverse remodeling after cardiac resynchronization therapy in patients with ischemic cardiomyopathy.
Aged; Aged, 80 and over; Cardiac Pacing, Artificial; Cardiomyopathies/complications/therapy; Female; Humans; Male; Middle Aged; Mitral Valve Insufficiency/complications; Pacemaker, Artificial; Sensitivity and Specificity; Severity of Illness Index; Ventricular Remodeling
Abstract :
[en] This study investigated the impact of ischemic mitral regurgitation (MR) severity and viability on left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy. Severe MR and ischemic cardiomyopathy have been associated with lack of LV reverse remodeling after CRT. Fifty-seven consecutive patients with ischemic MR, LV ejection fraction < or =35%, QRS duration > or =120 ms, and intraventricular dyssynchrony > or =50 ms were prospectively included. Stress echocardiography was performed before CRT implantation. Viability in the region of the LV pacing lead was defined as the presence of viability in 2 contiguous segments. Response to CRT at 6 months was defined by evidence of > or =15% LV decrease in end-systolic volume. Severe MR was defined by an effective regurgitant orifice (ERO) area > or =20 mm(2). Thirty-three patients (58%) were responders at follow-up. Baseline ERO area and prevalence of severe MR were not different between responders and nonresponders (19 +/- 11 vs 21 +/- 13 mm(2), p = 0.67; 52% vs 53%, p = 0.84). In responders, MR was decreased by 58% (ERO 19 +/- 12 to 8 +/- 6 mm(2)). In the presence of viability in the region of the pacing lead, 74% (n = 29 patients) were responders (sensitivity 88%, specificity 58%); in the subgroup of patients with viability in the region of the pacing lead and severe MR, 83% (n = 17 patients) were responders. In conclusion, LV remodeling is frequent and ischemic MR decrease important in patients with viability in the region of the pacing lead without regard to MR severity.
Disciplines :
General & internal medicine Cardiovascular & respiratory systems
Author, co-author :
Senechal, Mario; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie
Lancellotti, Patrizio ; Université de Liège - ULiège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie
Magne, Julien ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Garceau, Patrick; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie
Champagne, Jean; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie
Philippon, Francois; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie
O'Hara, Gilles; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie
Moonen, Marie ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Dubois, Michelle; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada > Département de cardiologie
Language :
English
Title :
Impact of mitral regurgitation and myocardial viability on left ventricular reverse remodeling after cardiac resynchronization therapy in patients with ischemic cardiomyopathy.
Publication date :
01 July 2010
Journal title :
American Journal of Cardiology
ISSN :
0002-9149
eISSN :
1879-1913
Publisher :
Elsevier Science, New York, United States - New York
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