Action Potentials; Adult; Aged; Amyotrophic Lateral Sclerosis/diagnosis/physiopathology; Electric Stimulation; Female; Humans; Longitudinal Studies; Male; Middle Aged; Motor Neurons; Muscle, Skeletal/innervation/physiopathology; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Thumb/physiopathology
Abstract :
[en] METHOD: The adapted multiple point stimulation (AMPS) method for calculating motor unit numbers (MUNE) was applied in 12 patients with amyotrophic lateral sclerosis (ALS) before riluzole therapy (T(0)) and again after 4, 8 and 12 months of treatment. RESULTS: Paired Student's t-test indicated a significant decrease of thenar MUNE and compound muscle action potential (CMAP) size at each 4-monthly interval, while average surface motor unit potential (SMUP) size did not change significantly over time. The rate of motor unit (MU) loss at month 4 was more than 20% in six patients (group 1) and less than 20% in six other patients (group 2). Comparison of groups 1 and 2 by Mann-Whitney U-testing indicated that percent changes in thenar MUNE and CMAP size compared to baseline were significantly different at months 4, 8 and 12, while no difference between the two groups was found for average SMUP size variations. In the group with a slow rate of MU loss, CMAP size remained stable, while in the group with a rapid rate of MU loss, there was a dramatic reduction in size of the CMAP. A positive correlation was found between percent change in thenar MUNE at T(4) and at T(12) (P < 0.001). CONCLUSION: AMPS is a useful technique to document MUNE, SMUP size and CMAP size changes over time in patients with ALS.
Disciplines :
Neurology
Author, co-author :
Wang, François-Charles ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Bouquiaux, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
De Pasqua, Victor ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Delwaide, Paul ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Changes in motor unit numbers in patients with ALS: a longitudinal study using the adapted multiple point stimulation method.
Publication date :
2002
Journal title :
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Bromberg M.B., Larson W.L. (1996) Relationships between motor-unit number estimates and isometric strength in distal muscles in ALS/MND. J. Neurol. Sci 139(SUPPL.).
Bromberg M.B. (1998) Electrodiagnostic studies in clinical trials for motor neuron disease. J. Clin. Neurophysiol 15:117-128.
Felice K.J. (1997) A longitudinal study comparing thenar motor unit number estimates to other quantitative tests in patients with amyotrophic lateral sclerosis. Muscle Nerve 20:179-185.
Yuen E.C., Olney R.K. (1997) Longitudinal study of fiber density and motor unit number estimate in patients with amyotrophic lateral sclerosis. Neurology 49:573-578.
McComas A.J., Fawcett P.R., Campbell M.J., Sica R.E. (1971) Electrophysiological estimation of the number of motor units within a human muscle. J. Neurol. Neurosurg. Psychiatry 34:121-131.
Doherty T.J., Brown W.F. (1993) The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle Nerve 16:355-366.
Wang F.C., Delwaide P.J. (1995) Number and relative size of thenar motor units estimated by an adapted multiple point stimulation method. Muscle Nerve 18:969-979.
Stashuk D.W., Doherty T.J., Kassam A., Brown W.F. (1994) Motor unit number estimates based on the automated analysis of F-responses. Muscle Nerve 17:881-890.
Brown W.F., Strong M.J., Snow R. (1988) Methods for estimating numbers of motor units in biceps-brachialis muscles and losses of motor units with aging. Muscle Nerve 11:423-432.
Daube J.R. (1988) Statistical estimates of number of motor units in thenar and foot muscles in patients with amyotrophic lateral sclerosis or the residual of poliomyelitis. Muscle Nerve 11:957.
Wang F.C., Delwaide P.J. (1998) Number and relative size of thenar motor units in ALS patients: Application of the adapted multiple point stimulation method. Electroencephalogr. Clin. Neurophysiol 109:36-43.
Brooks B.R. (1994) El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. J Neurol Sci , Sub-committee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral contributors; 124(SUPPL.).
Wang F.C., Delwaide P.J. (1995) An adapted multiple point stimulation (AMPS) method for estimating the number and size of motor units. Electroencephalogr. Clin. Neurophysiol 97(SUPPL.).
Erlanger J., Gasser H.S. (1937) Electrical signs of nervous activity., (Thesis). Philadelphia: University of Pennsylvania Press; .
Galea V., de Bruin H., Cavasin R., McComas A.J. (1991) The numbers and relative sizes of motor units estimated by computer. Muscle Nerve 14:1123-1130.
Dengler R., Kossev A., Wohlfahrt K., Schubert M., Elek J., Wolf W. (1992) F waves and motor unit size. Muscle Nerve 15:1138-1142.
Brown W.F., Milner-Brown H.S. (1976) Some electrical properties of motor units and their effects on the methods of estimating motor unit numbers. J. Neurol. Neurosurg. Psychiatry 39:249-257.
Dantes M., McComas A. (1991) The extent and time course of motoneuron involvement in amyotrophic lateral sclerosis. Muscle Nerve 14:416-421.
Arasaki K., Tamaki M. (1998) A loss of functional spinal alpha motor neurons in amyotrophic lateral sclerosis. Neurology 51:603-605.
Emeryk-Szajewska B., Kopec J., Karwanska A. (1997) The reorganization of motor units in motor neuron disease. Muscle Nerve 20:306-315.
Daube J.R. (2000) Electrodiagnostic studies in amyotrophic lateral sclerosis and other motor neuron disorders. Muscle Nerve 23:1488-1502.
Wang F.C., De Pasqua V., Gerard P., Delwaide P.J. (2001) Prognostic value of decremental responses to repetitive nerve stimulation in ALS patients. Neurology 57:897-899.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.