[en] To study regulation of the secretion of human pituitary GH (hGH) and placental GH (hPGH) in the pregnant woman and human fetus, the GH-releasing factor Sermorelin [GRF-(l–29)-NH2] was administered to pregnant women at term (n = 5), just before elective cesarean section; saline was administered in control studies (n = 5). The effects of GRF-(1–29)-NH2 administration on maternal and fetal serum concentrations of hGH and GRF-(l–29)-NH2 and maternal serum levels of hPGH were evaluated at birth. The mean time span between injection and birth was 20 min (range, 15–25 min). Cord serum hGH concentrations were similar in infants of GRF-(1–29)-NH2-injected mothers and control infants. GRF-(l–29)-NH2 elicited a consistent but small rise in maternal hGH serum concentrations (P = 0.08), whereas hPGH concentrations remained unaltered. Finally, GRF-(l–29)-NH2 concentrations were undetectable in cord serum, but readily detectable in concomitantly obtained maternal serum.
In conclusion, these data suggest that hGH secretion in the pregnant woman at term is suppressed at the pituitary level, that GRF does not affect hPGH secretion, and that fetal hGH secretion is independent of circulating maternal GRF, probably because of lack of transplacental GRF passage.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
De Zegher, F.
Vanderschueren-Lodeweyckx, M.
Spitz, B.
Faijerson, Y.
Blomberg, F.
Beckers, Albert ; Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Hennen, Georges ; Université de Liège - ULiège > Endocrinologie clinique
Frankenne, Francis; Université de Liège - ULiège > Département des sciences cliniques
Language :
English
Title :
Perinatal growth hormone (GH) physiology : effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH.
Publication date :
1990
Journal title :
Journal of Clinical Endocrinology and Metabolism
ISSN :
0021-972X
eISSN :
1945-7197
Publisher :
Endocrine Society, Chevy Chase, United States - Maryland
Seeburg PH. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. DNA. 1982;1:239-49.
Frankenne, F Rentier-Delrue F, Scippo ML, Martial J, Hennen G. Expression of the growth hormone variant gene in human placenta. J Clin Endocrinol Metab. 1987;64:635-7.
Igout A, Scippo ML, Frankenne F, Hennen G. Cloning and nucleotide sequence of placental hGH-V cDNA. Arch Int Physiol Biochem. 1988;96:63-7.
Scippo ML, Frankenne F, Van Beeumen J, Igout A, Hennen G. Human placental growth hormone: proof of identity with the GH-V gene product by N-terminal microsequence analysis. [Abstract B59]. Proc of the Annual Meet of the Soc of Belgian Biochemists. 1988.
Kaplan SL, Grumbach MM, Shepard TH. The ontogenesis of human fetal hormones. I. Growth hormone and insulin. J Clin Invest. 1972;51:3080-93.
Frankenne F, Closset J, Gomez F, Scippo ML, Smal J, Hennen G. The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant. J Clin Endocrinol Metab. 1988;66:1171-80.
Grumbach MM, Kaplan SL, Sciarra JJ, Burr IM. Chorionic growth hormone-prolactin (CGP): secretion, disposition, biologic activity in man, and postulated function as the ‘growth hormone’ of the second half pregnancy. Ann NY Acad Sci. 1968;148:501-31.
Spellacy WN, Buhi WC. Pituitary GH and PL levels measured in normal term pregnancy and at the early and late postpartum period. Am J Obstet Gynecol. 1969;105:888-896.
Vanderschueren-Lodeweyckx M, Wolter R, Malvaux P, Eggermont E, Eeckels R. The glucagon stimulation test: effect on plasma growth hormone and on immunoreactive insulin, cortisol and glucose in children. J Pediatr. 1974;85:182-7.
Shimano S, Suziki S, Nagashima K, Yagi H, Sakaguchi M, Ku-roume T. Growth hormone responses to growth hormone releasing factor in neonates. Biol Neonate. 1985;47:367-70.
Deiber M, Chatelain P, Naville D, Putet G, Salle B. Functional hypersomatotropism in small for gestational age (SGA) newborn infants. J Clin Endocrinol Metab. 1989;68:231-3.
Coxam V, Davicco MJ, Dardillat C, et al. Regulation of growth hormone release in fetal calves. Biol Neonate. 1988;54:160-8.
de Zegher F, Styne DM, Daaboul J, Bettendorf M, Kaplan SL, Grumbach MM. Hormone ontogeny in the ovine fetus and neonatal lamb. XX. Effect of age, breeding season and twinning on the growth hormone (GH) response to GH-releasing factor: evidence for a homeostatic role of fetal GH. Endocrinology. 1989;124:124-8.
Gluckman PD. Changing responsiveness to growth hormone releasing factor in the perinatal sheep. J Dev Physiol. 1984;6:509-15.
Ohmura E, Jansen A, Chernick V, et al. Human pancreatic growth hormone releasing factor (hpGRF-1-40) stimulates GH release in the ovine fetus. Endocrinology. 1984;114:299-301.
Frohman LA, Downs TR. Measurement of growth hormone-releasing factor. Methods Enzymol. 1986;124:371-89.
Gluckman PD, Parsons Y. Growth hormone secretion in the fetal sheep following stereotaxic electrolytic lesioning of the fetal hypothalamus. J Dev Physiol 1985;7:25-36.
Artenisio AC, Volpe A, Rayonese F, Maccarone G, Forte F, Consolo F. Behaviour of hPL and GH plasmatic rate in pregnant women at different time of their pregnancy during dynamic tests. Horm Metab Res. 1980;12:205-8.
Yen SSC, Vela P, Tsai CC. Impairment of growth hormone secretion in response to hypoglycemia during early and late pregnancy. J Clin Endocrinol Metab. 1970;31:29-32.