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Dramatic improvement of severe dilated cardiomyopathy in an acromegalic patient after treatment with octreotide and trans-sphenoidal surgery.
Legrand, Victor; Beckers, Albert; Pham, V. T. et al.
1994In European Heart Journal, 15 (9), p. 1286-9
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Keywords :
Acromegaly/complications; Adenoma/surgery; Cardiomyopathy, Dilated/therapy; Electrocardiography; Female; Heart Failure/therapy; Hemodynamics; Humans; Middle Aged; Octreotide/therapeutic use; Pituitary Neoplasms/surgery
Abstract :
[en] Severe congestive heart failure developed in an acromegalic patient, and was successfully treated with octreotide followed by trans-sphenoidal surgery. Clinical, hormonal echocardiographic and haemodynamic findings as well as histological heart examination before and after treatment revealed that over-production of growth hormone may induce the myocardial cell degeneration responsible for mechanical heart dysfunction. In addition, this unique example demonstrates the reversibility of myocardial damage following octreotide and trans-sphenoidal surgery, leading to significant improvement in cardiac function with minimal diastolic dysfunction and moderate interstitial fibrosis.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Legrand, Victor ;  Université de Liège - ULiège > Cardiologie
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Pham, V. T.
Demoulin, J. C.
Stevenaert, Achille ;  Université de Liège - ULiège > Neurochirurgie
Language :
English
Title :
Dramatic improvement of severe dilated cardiomyopathy in an acromegalic patient after treatment with octreotide and trans-sphenoidal surgery.
Publication date :
September 1994
Journal title :
European Heart Journal
ISSN :
0195-668X
eISSN :
1522-9645
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
15
Issue :
9
Pages :
1286-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 May 2010

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