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Tgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons
LEFEBVRE, Philippe; Staecker, H.; Weber, T. et al.
1991In Neuroreport, 2 (6), p. 305-8
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Abstract :
[en] Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular receptors for bFGF in several cell types. In this study, we show that TGFss1 is expressed in cultured adult mouse auditory neurons in response to explanation injury and acts in an autocrine fashion to increase the level of expression of bFGF receptors message in these same neurons. Based on these in-vitro results, we propose that these trophic factors (i.e. TGFss1 and bFGF) play a significant role in the response to injury by the mature auditory system.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Biochemistry, biophysics & molecular biology
Author, co-author :
LEFEBVRE, Philippe 
Staecker, H.
Weber, T.
Van de Water, T. R.
Rogister, Bernard  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Language :
English
Title :
Tgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons
Publication date :
June 1991
Journal title :
Neuroreport
ISSN :
0959-4965
eISSN :
1473-558X
Publisher :
Lippincott Williams & Wilkins, United States
Volume :
2
Issue :
6
Pages :
305-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 May 2010

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