Article (Scientific journals)
Effect of aggregation on bacteriochlorin a triplet-state formation: A laser flash photolysis study
Damoiseau, Xavier; Tfibel, Francis; Hoebeke, Maryse et al.
2002In Photochemistry and Photobiology, 76 (5), p. 480-485
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Keywords :
bacteriochlorin; photodynamic therapy; laser flash phtolysis
Abstract :
[en] Bacteriochlorin a (BCA) is a potential photosensitizer for photodynamic therapy of cancer. It has been shown previously that the photoefficiency of the dye is mainly dependent on singlet oxygen (O-1(2)) generation. Nanosecond laser flash photolysis was used to produce and to investigate the excited triplet state of the dye in methanol, phosphate buffer and dimiristoyl-L-alpha-phosphatidylcholine (DMPC) liposomes. The transients were characterized in terms of their absorption spectra, decay kinetics, molar absorption coefficients and formation quantum yield of singlet-triplet intercrossing. The lifetime of the BCA triplet state was measured at room temperature. The triplet-state quantum yield is quite high in methanol (0.7) and in DMPC (0.4) but only 0.095 in phosphate buffer. In the last case, BCA is in a monomer-dimer equilibrium, and the low value of the quantum yield observed was ascribed to the fact the triplet state is only formed by the monomers.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Damoiseau, Xavier
Tfibel, Francis
Hoebeke, Maryse  ;  Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale
Fontaine-Aupart, Marie-Pierre
Language :
English
Title :
Effect of aggregation on bacteriochlorin a triplet-state formation: A laser flash photolysis study
Publication date :
November 2002
Journal title :
Photochemistry and Photobiology
ISSN :
0031-8655
Publisher :
Amer Soc Photobiology, Augusta, United States - Georgia
Volume :
76
Issue :
5
Pages :
480-485
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 May 2010

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