Chitin/therapeutic use; Diabetes Mellitus, Type 1/complications/pathology; Diabetes Mellitus, Type 2/complications/pathology; Double-Blind Method; Emollients/therapeutic use; Female; Foot Dermatoses/drug therapy/pathology; Galvanic Skin Response/drug effects; Humans; Menopause; Middle Aged; Skin/drug effects/pathology; Treatment Outcome; Water/analysis; Water Loss, Insensible/drug effects; beta-Glucans/therapeutic use
Abstract :
[en] BACKGROUND: Corneocyte accumulation (hyperkeratosis, xerosis) commonly occurs in the stratum corneum (SC) of the feet of diabetic patients, as well as menopausal women. OBJECTIVE: To compare the effects of a 2.5% chitin-glucan formulation with its placebo, and commercially available glycerol formulations. METHODS: This two-step controlled double-blind, randomized, intra-individual study was performed in 30 type 1 and 2 diabetic menopausal women suffering from xerosis of the feet. The formulations were applied once daily for 3 weeks. Electrometric assessments were performed on three sites of the feet at entry in the study, at weekly intervals during the treatment phase, and in a 2-week follow-up out of treatment. Positive controls consisted in two commercially available formulations enriched in glycerol. RESULTS: Data revealed an unequivocal benefit provided by the 2.5% chitin-glucan formulation compared with placebo. The electrometric values were significantly higher at each evaluation time during both treatment and follow-up phases. The two glycerol-enriched formulations showed slightly different kinetics of SC moisturization. A steep increase was followed by a plateau level and a rapid decline after stopping the treatments. CONCLUSION: The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles.
Disciplines :
Dermatology
Author, co-author :
Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Tsuruta D, Green K, Gessios S, Jones J. The barrier function of skin: how to keep a tight lid on water loss. Trends Cell Biol 2002;12:355-357 (Pubitemid 35015139)
Short RW, Chan JL, Choi JM, et al. Effects of moisturization on epidermal homeostasis and differentiation. Clin Exp Dermatol 2007;32:88-90 (Pubitemid 46006376)
Piérard GE, Goffin V, Hermanns-Lê T, Piérard- Franchimont C. Corneocyte desquamation. Int J Mol Med 2000;6:217-221
Pirot F, Morel B, Peyrot G, et al. Effects of osmosis on water-holding capacity of stratum corneum and skin hydration. Exog Dermatol 2003;2:252-257 (Pubitemid 38916087)
Harding CR. The stratum corneum: structure and function in health and disease. Dermatol Ther 2004;17:6-15 (Pubitemid 38248643)
Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol 2005;124:1099-1110 •• Original work alluding to the molecular biology of xerosis.
Loden M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 2003;4:771-788 • In-depth review of recent trends in the management of xerosis.
Rawlings AV. Trends in stratum corneum research and the management of dry skin conditions. Int J Cosmet Sci 2003;25:63-95 (Pubitemid 36741164)
Gloor M. How do dermatological vehicles influence the horny layer ? Skin Pharmacol Phyiol 2004;7:267-273
Rawlings AV, Canestrari DA, Dobkowski B. Moisturizer technology versus clinical performance. Dermatol Ther 2004;17:49-56 (Pubitemid 38248648)
Xhauflaire-Uhoda E, Fontaine K, Piérard GE. Kinetics of moisturizing and firming effects of cosmetic formulations. Int J Cosmet Sci 2008;30:131-138
Harding CR, Watkinson A, Rawlings A, et al. Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci 2000;22:21-52
Thau P. Glycerin (glycerol): current insights into the functional properties of a classic cosmetic raw material. J Cosmet Sci 2002;53:229-236
Fluhr JW, Darlenski R, Suber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol 2008;159:23-34 (Pubitemid 351874509)
Piérard GE. What do you mean by dry skin? Dermatologica 1989;179:1-2
Piérard-Franchimont C, Piérard GE. Beyond a glimpse at seasonal dry skin: a review. Exog Dermatol 2002;1:3-6
Jackson SM, Williams ML, Feingold KR, Elias PM. Pathobiology of the stratum corneum. West J Med 1993;158:279-285
Sanders JE, Goldstein BS, Leotta DF. Skin response to mechanical stress: adaptation rather than breakdown. J Rehabil Res Dev 1995;32:214-226
Piérard-Franchimont C, Letawe C, Goffin V, Piérard GE. Skin waterholding capacity and transdermal estrogen therapy for menopause: a pilot study. Maturitas 1995;22:151-154
Paquet F, Piérard-Franchimont C, Fumal I, et al. Sensitive skin at menopause: dew point and electrometric properties of the stratum corneum. Maturitas 1998;28:221-227 (Pubitemid 28162434)
Pham HT, Exelbert L, Segal-Owens A, Veves A. A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes. Ostomy Wound Manage 2002;48:30-36
Quatresooz P, Piérard-Franchimont C, Kharfi M, et al. Skin in maturity. The endocrine and neuroendocrine pathways. Int J Cosmet Sci 2007;29:1-6 (Pubitemid 46252964)
Bevans JS. Biomechanical, neuropathic and metabolic factors in the formation of plantar callus and diabetes. Br J Pediatr 2003;2:61-65
Uhoda E, Debatisse B, Paquet P, et al. The so-called dry skin of the diabetic patient. Rev Med Liège 2005;60:560-563 (Pubitemid 40941542)
Flagothier C, Bourguignon R, Piérard-Franchimont C, Piérard GE. Cutaneous stigmata of diabetes mellitus. Rev Med Liège 2005;60:553-559
Leymarie F, Richard JL, Malgrange D. Factors associated with diabetic patients at high risk for foot ulceration. Diabetes Metab 2005;31:603-605 (Pubitemid 43001180)
Bennett PJ, Stocks AE, Whittam DJ. Analysis of risk factors for neuropathic foot ulceration in diabetes mellitus. J Am Podiatr Med Assoc 1996;86:112-116 (Pubitemid 126671359)
Murray HJ, Young MJ, Hollis S, Boulton AJ. The association between callus formation, high pressures and neuropathy in diabetic foot ulceration. Diabetes Med 1996;13:979-982 (Pubitemid 26384122)
Booth J, McInnes A. The aetiology and management of plantar callus formation. J Wound Care 1997;6:427-430
Pataky Z, Golay A, Faravel L, et al. The impact of callosities on the magnitude and duration of plantar pressure in patients with diabetes mellitus. A callus may cause 18,600 kilograms of excess plantar pressure per day. Diabetes Metab 2002;28:356-361
Berardesca E. EEMCO guidance for the assessment of stratum corneum hydration: electrical methods. Skin Res Technol 1997;3:126-132 •• Comprehensive survey of biophysical methods measuring stratum corneum hydration.
Lee CM, Maibach HI. Bioengineering analysis of water hydration: an overview. Exog Dermatol 2002;1:269-275
Fischer TW, Wiggeralberti W, Elsner P. Assessment of « dry skin »: current bioengineering methods and test designs. Skin Pharmacol Appl Skin Physiol 2001;14:183-195
Züllii F, Suter F, Biltz H, Nissen HP. Improving skin function with CM-glucan, a biological response modifier from yeast. Int J Cosmet Sci 1998;20:79-86 (Pubitemid 28144319)
Morganti P, Muzzarelli RAA, Muzzarelli C. Multifunctional use of innovative chitin nanofibrils for skin care. J Appl Cosmetol 2006;24:105-114 (Pubitemid 44831864)
Gautier S, Xhauflaire-Uhoda E, Gonry P, Piérard GE. Chitin-glucan, a natural cell scaffold for skin rejuvenation: in vivo safety and efficacy. Int J Cosmet Sci 2008;30:459-469 • First paper on the biological effects of chitin-glucan.
Treffel P, Gabard B. Stratum corneum dynamic function measurements after moisturizer or irritant application. Arch Dermatol Res 1995;287:474-479
Clarys P, Barel OA, Gabard B. Non-invasive electrical measurements for the evaluation of the hydration state of the skin: comparison between three conventional instruments, the Corneometer®, the Skicon® and the Nova DPM®. Skin Res Technol 1999;5:14-20 (Pubitemid 29048034)
Fluhr JW, Gloor M, Lazzerini S, et al. Comparative study of five instruments measuring stratum corneum hydration (Corneometer CM820 and CM825, Skicon 200, Nova DPM 9003, Dermalab). Skin Res Technol 1999;5:171-178 (Pubitemid 29346750)
Goffin V, Piérard-Franchimont C, Piérard GE. Passive sustainable hydration of the stratum corneum following surfactant challenge. Clin Exp Dermatol 1999;24:208-311 (Pubitemid 29366914)
Van Cromphaut I, Fumal I, Jacquemin D, et al. Skin barrier repair after burns. Electrometric evaluation using the passive sustainable hydration test. J Environ Med 1999;1:47-50
Visscher MO, Tolia GT, Wickett RR, Hoath SB. Effect of soaking and natural moisturizing factor on stratum corneum water-handling properties. J Cosmet Sci 2003;54:289-300
Uhoda E, Piérard-Franchimont C, Debatisse B, et al. Repair kinetics of stratum corneum under repeated insults. Exog Dermatol 2004;3:7-11 • Important contribution about repair kinetics of the stratum corneum.
Xhauflaire-Uhoda E, Thirion L, Piérard-Franchimont C, Piérard GE. Comparative effect of tacrolimus and betamethasone valerate on the passive sustainable hydration of the stratum corneum in atopic dermatitis. Dermatology 2007;214:328-332 (Pubitemid 46659016)
Kligman A. Regression method for assessing the efficacy of moisturizers. Cosmet Toil 1978;93:27-35 • The research described in this article formed the basis of kinetic studies on skin moisturizers.
Rosado C, Pinto P, Rodrigues LM. Modeling TEWL-desorption curves: a new practical approach for the quantitative in vivo assessment of skin barrier. Exp Dermatol 2005;14:386-390 (Pubitemid 40691661)
Pouillot A, Dayan N, Polla AS, et al. The stratum corneum: a double paradox. J Cosmet Dermatol 2008;7:143-148
Marks R. The stratum corneum barrier: the final frontier. J Nutr 2004;134:2017S-21S (Pubitemid 39031269)