Further evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study

[en] In the biosocial model of Cloninger, three major personality dimensions, novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are dependent on central monoaminergic systems, respectively dopaminergic, serotonergic, and noradrenergic. This study investigated the relationships between these major personality dimensions and growth hormone (GH) responses to both apomorphine and clonidine challenge tests in healthy subjects. GH responses to apomorphine were significantly correlated with NS when peak relative values were considered (r=0.47, P=0.03). HA and RD did not show any relationships with the endocrine responses. In contrast, no significant relationship existed between GH responses to clonidine and any of the three temperament dimensions. These results gave another support of the hypothesized link between NS and dopaminergic central neurotransmission. In contrast, the results did not confirm the association between RD and noradrenergic central neurotransmission, probably because RD is poorly validated. This partial confirmation might suggest that the link between personality traits and neurotransmission systems is probably indirect. (C) 2002 Elsevier Science Ltd. All rights reserved.

Research Center/Unit :

Centre de Neurosciences Comportementale et Cognitive

Disciplines :

Neurosciences & behavior
Social, industrial & organizational psychology

Author, co-author :

Hansenne, Michel ; Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles

Pinto, Emmanuel ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Reggers, Jean ; Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E - Psychiatrie et psychologie médicale

Scantamburlo, Gabrielle ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Moor, Marie

Ansseau, Marc ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Language :

English

Title :

Further evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study

Publication date :

2002

Journal title :

Personality and Individual Differences

ISSN :

0191-8869

eISSN :

1873-3549

Publisher :

Pergamon Press - An Imprint of Elsevier Science, Oxford, United Kingdom

Volume :

Issue :

Pages :

967-977

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 January 2009

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