[en] [en] BACKGROUND: This multi-centric study aimed to explore differences in brain activity patterns in patients with disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS).
METHODS: Using high-density electroencephalographic (EEG) recordings from 368 DoC patients, 39 who emerged from MCS (eMCS), and 73 healthy controls, we examined instantaneous functional connectivity-based meta-states acting as attractors in a dynamical system, extracted by means of community detection algorithms and recurrence analysis. We analyzed data from two patient cohorts and included resting-state and auditory processing tasks in four frequency bands (delta, theta, alpha, beta) and from three perspectives, namely: (i) discrete activation of dominant states, (ii) a dynamical system composed of attractor states and (iii) the correlation and anticorrelation patterns of the active states.
RESULTS: Findings revealed that while the overall structure of brain connectivity remained stable after injury, patients with DoC and those who emerged showed notable differences in the speed and consistency of how their brain states activated. Specifically, in higher frequencies, UWS patients exhibited faster, and less stable dynamics, shorter dwell times and decreased meta-state anticorrelation compared to those in MCS and eMCS. Moreover, a four-way combined learning classification analysis showed that the measures were able to distinguish the UWS and MCS subgroups.
SIGNIFICANCE: These brain state dynamics could serve as valuable markers for assessing states of consciousness. Our results highlight the potential of using high-temporal resolution dynamic brain activity patterns to improve the understanding of altered consciousness and their application to clinical settings.
Disciplines :
Neurosciences & behavior
Author, co-author :
Nunez Novo, Pablo ; Coma Science Group, GIGA-Consciousness, GIGA Institute, University of Liège, Liège, Belgium, NeuroRehab & Consciousness Clinic, Neurology Department, University Hospital of Liège, Liège, Belgium, Biomedical Engineering Group, University of Valladolid, Valladolid, Spain, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, (CIBER-BBN), Madrid, Spain. Electronic address: P.Nunez@uliege.be
Tewarie, Prejaas ; Clinical Neurophysiology Group, University of Twente, Enschede, the Netherlands, Sir Peter Mansfield Imaging Centre, School of Physics, University of Nottingham, United Kingdom, CERVO Brain Research Centre, Laval University, Québec, Canada
Rodríguez-González, Víctor ; Biomedical Engineering Group, University of Valladolid, Valladolid, Spain, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, (CIBER-BBN), Madrid, Spain
Alnagger, Naji ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Fundação Bial KBFUS - King Baudouin Foundation United States F.R.S.-FNRS - Fonds de la Recherche Scientifique ERDF - European Regional Development Fund FWO - Research Foundation Flanders MSF - Mind Science Foundation KBS - Koning Boudewijnstichting Fonds Léon Fredericq ISCIII - Instituto de Salud Carlos III NSCF - National Natural Science Foundation of China EC - European Commission Marie Skłodowska-Curie Actions
Funding text :
We thank the patients, their families and the control subjects for participating in our study. The authors extend their gratitude to the entire staff of the ICU, Nuclear Medicine and Radiodiagnostic departments at the University Hospital of Li\u00E8ge. We are especially thankful to the members of the Coma Science Group for their assistance with the clinical evaluations. This work was supported by the University and University Hospital of Li\u00E8ge, the Belgian National Funds for Scientific Research (FRS-FNRS), the FNRS PDR project (T.0134.21), the FNRS MIS project (F.4521.23), the FLAG-ERA JTC2021 project ModelDXConsciousness (Human Brain Project Partnering Project) and FLAG-ERA JTC 2023 - HBP - Basic and Applied Research, project BrainAct, the program Investissements d'avenir ANR-10-IAIHU-06, JTC the fund Generet, the King Baudouin Foundation, the BIAL Foundation, the Funds Chantal Schaeck Yolande, the T\u00E9l\u00E9vie Foundation, the Mind Science Foundation, the European Commission, the Fondation Leon Fredericq, the Mind-Care foundation, the National Natural Science Foundation of China (Joint Research Project 81471100), the European Foundation of Biomedical Research FERB Onlus, the Horizon 2020 MSCA \u2013 Research and Innovation Staff Exchange DoC-Box project (HORIZON-MSCA-2022-SE-01-01; 101131344), by \"MICIU/AEI/10.13039/501100011033\u2033 and \"ERDF A way of making Europe\" through the project PID2022-138286NB-I00, and \"CIBER en Bioingenier\u00EDa, Biomateriales y Nanomedicina (CIBER-BBN)\" through \"Instituto de Salud Carlos III\" co-funded with ERDF funds. NA and MMV are research fellows, OG and AT are research associates, and SL is research director at the F.R.S.-FNRS. JA is postdoctoral fellow at the FWO (1265522N).
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