EEG; disorders of consciousness; neural activity modeling; neural correlates of consciousness; neural field theory; Experimental and Cognitive Psychology; Clinical Psychology; Neurology; Neurology (clinical); Psychiatry and Mental Health
Abstract :
[en] Understanding the neural correlates of consciousness remains a central challenge in neuroscience. In this study, we explore the potential of neural field theory (NFT) as a computational framework for representing consciousness states. While prior research has validated NFT's capacity to differentiate between normal and pathological states of consciousness, the relationship of its parameters to the representation of consciousness states remains unclear. Here, we fitted a corticothalamic NFT model to the electroencephalography (EEG) data collected from healthy individuals and patients with disorders of consciousness. We then comprehensively explored the correlations between the fitted NFT parameters and features extracted from both experimental and simulated EEG data across various states of consciousness. The identified correlations not only highlight the model's ability to differentiate between healthy and impaired states of consciousness, but also shed light on the physiological bases of these states, pinpointing potential biomarkers. Our results provide valuable insights into how consciousness levels are represented within the NFT framework and into the dynamics of brain activity across normal and pathological states of consciousness. This underscores the potential of NFT as a useful tool for consciousness research, facilitating in-silico experimentation.
Disciplines :
Neurosciences & behavior
Author, co-author :
Polyakov, Daniel ; Department of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, David Ben Gurion Blvd 1, Be'er-Sheva 8410501, Israel
Robinson, P A; School of Physics, The University of Sydney, Sydney, NSW 2006, Australia
Makbili, Avigail; Department of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, David Ben Gurion Blvd 1, Be'er-Sheva 8410501, Israel
Laureys, Steven ; Université de Liège - ULiège > Département des sciences cliniques ; Joint International Research Unit on Consciousness, CERVO Brain Research Centre, Laval University, 2601 de la Canardière, G1J 2G3, Québec, Canada
Gosseries, Olivia ✱; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Shriki, Oren ✱; Department of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, David Ben Gurion Blvd 1, Be'er-Sheva 8410501, Israel
✱ These authors have contributed equally to this work.
Language :
English
Title :
Neural field modeling and analysis of consciousness states in the brain.
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