[en] [en] OBJECTIVE: Neuroimaging investigations are critical to provide a more direct assessment of brain disturbances associated with osteoarthritis (OA)-related pain, and to better understand its pathophysiology to develop new treatment strategies. This viewpoint aims to summarize the importance of the brain in OA pain.
METHOD: A European working group on pain in osteoarthritis GO-PAIN (Going Inside Osteoarthritis-related Pain Phenotyping) has been created to work on a global assessment of the OA-related pain. Relevant scientific literature was evaluated, summarized and discussed to expose advances in functional brain alterations related-to OA pain.
RESULTS: Findings of neuroimaging studies are highly heterogenous and based on small sample size, but some key brain alterations associated with OA pain can be identified across experiments. A systematic literature review conducted by Hall and colleagues (2023) found lower activity, connectivity, and grey matter volume in the right anterior insula in patients with OA than in healthy controls. Other works also pointed out that activity of specific brain regions could serve as a potential surrogate biomarker, but several limitations and confounding factors needs to be addressed.
CONCLUSIONS: Brain functional imaging provides opportunities to accurately address an OA-related pain endophenotype. To encompass limitations and fill the gaps from the previous studies, we propose a blueprint for the next 5 years and stimulate ideas for others working in the field.
Disciplines :
Rheumatology
Author, co-author :
Fauchon, Camille; University of Clermont Auvergne, CHU Clermont-Ferrand, Inserm, Neuro-Dol, Clermont-Ferrand, France
Binvignat, Marie; Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ; Centre de Recherche Saint-Antoine (CRSA) Inserm UMRS-938, Sorbonne Université, Paris, France
Berenbaum, Francis; Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ; Centre de Recherche Saint-Antoine (CRSA) Inserm UMRS-938, Sorbonne Université, Paris, France
Conaghan, Philip G; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK ; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Peyron, Roland; Université Jean Monnet, CHU Saint-Etienne, Inserm UMR-1028, CRNL, NeuroPain, Saint-Etienne, France
Sellam, Jérémie; Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ; Centre de Recherche Saint-Antoine (CRSA) Inserm UMRS-938, Sorbonne Université, Paris, France
Going Inside Osteoarthritis-Related Pain Phenotyping (GO-PAIN) network members
Henrotin, Yves ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Pathologie générale et physiopathologie - Techniques particulières de kinésithérapie
Language :
English
Title :
Brain functional imaging contributions in osteoarthritis-related pain: A viewpoint.
NIHR - National Institute for Health Research ANR - Agence Nationale de la Recherche NIHR BRC - NIHR Imperial Biomedical Research Centre
Funding text :
NEURON-ERA-NET (Network of European Funding for Neuroscience Research) and Association Fran\u00E7aise de Lutte Antirhumatismale. CF holds a junior professor chair at the University of Clermont Auvergne. MB is supported by the French Society of Rheumatology, Pfizer Advance 2020 grant, Sorbonne University doctoral fellowship and Osteoarthritis Foundation mobility grant. PGC is supported in part by the National Institute for Health and Care Research (NIHR203331) and Leeds Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Marie Binvignat is supported by the French Society of Rheumatology, Pfizer Advance 2020 grant, Sorbonne University doctoral fellowship and Osteoarthritis Foundation mobility grant.
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