PROMs; SarQoL; meta‐analysis; psychometric properties; quality of life; sarcopenia; Humans; Surveys and Questionnaires; Reproducibility of Results; Aged; Psychometrics/methods; Quality of Life; Sarcopenia/psychology; Sarcopenia/diagnosis
Abstract :
[en] [en] BACKGROUND: The Sarcopenia and Quality of Life (SarQoL) questionnaire is recognized as the only disease-specific patient-reported outcome measure (PROM) for assessing sarcopenia-related HRQoL. This systematic review and meta-analysis aimed to provide a quantitative summary of all evidence reported on the reliability, validity, responsiveness and floor/ceiling effects of SarQoL in older adults.
METHODS: Following PRISMA-COSMIN guidelines, a systematic search for studies evaluating the psychometric properties of SarQoL (i.e., reliability, validity, responsiveness and floor and ceiling effects) in older people was conducted on MEDLINE (via OVID), PsycINFO, Scopus and EMBASE. Studies published between 2013 and November 2024 using a consensual definition of sarcopenia were included. Study selection and data extraction were made by two independent reviewers. A random-effects model meta-analysis was applied. PROSPERO registration: CRD42024546880.
RESULTS: From 411 studies identified by the search strategy, 25 fulfilled the inclusion criteria, including 4585 community-dwelling individuals, of which 1311 were diagnosed as sarcopenic. SarQoL demonstrated high reliability (pooled Cronbach's alpha values consistently exceeding 0.80) and excellent test-retest reliability (pooled ICC = 0.98). Construct validity was confirmed with strong convergent correlations (pooled r > 0.54) with related dimensions of generic SF-36 and EQ-5D and weaker divergent correlations (pooled r < 0.47). Responsiveness, evaluated in two studies using different methodologies, supported the ability of SarQoL to detect meaningful changes in HRQoL. The certainty of evidence was rated as high for reliability, validity and responsiveness.
CONCLUSION: This meta-analysis consolidates a decade of evidence and confirms the strong psychometric properties of SarQoL, with a high level of evidence.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Demonceau, Céline ; Université de Liège - ULiège > Unité de recherche Santé publique, épidémiologie et économie de la santé (URSAPES)
Christian, Brabant; Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Emmanuel, Shukuru; Public Health Aging Research & Epidemiology (PHARE)Group, Research Unit in Clinical Pharmacologyand Toxicology (URPC), Department of Biomedical Sciences‑Faculty of Medicine, NAmur Research Institute for LIfeSciences (NARILIS), University of Namur, Namur, Belgium
Alokail, Majed ; Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
Al-Daghri, Nasser ; Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
Rolland, Yves ; IHU HealthAge, Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France
Bautmans, Ivan ; Gerontology Department and Frailty in Ageing Research Department, Vrije Universiteit Brussel, Brussels, Belgium
Bauer, Jürgen M; Center for Geriatric Medicine and Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany
Cherubini, Antonio ; Geriatria, Accettazione Geriatrica e Centro di Ricerca per l'Invecchiamento, IRCCS INRCA, Ancona, Italy ; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy
Cruz-Jentoft, Alfonso J; Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
Dawson-Hughes, Bess ; Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
Fielding, Roger A ; Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Centeron Aging, Tufts University, Boston, Massachusetts, USA
Harvey, Nicholas C ; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK
Visser, Marjolein ; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam and the Amsterdam Public Health Research Institute, Amsterdam, the Netherlands
Duque, Gustavo; Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada ; Department of Medicine, McGill University, Montreal, Quebec, Canada
Rizzoli, René ; Service of Bone Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland
Reginster, Jean-Yves ; Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Beaudart, Charlotte ; Public Health Aging Research & Epidemiology (PHARE)Group, Research Unit in Clinical Pharmacologyand Toxicology (URPC), Department of Biomedical Sciences‑Faculty of Medicine, NAmur Research Institute for LIfeSciences (NARILIS), University of Namur, Namur, Belgium
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