addiction; biomarkers; homocysteine; international network; methylmalonic acid; multidisciplinary; neurology; nitrous oxide; toxicology; Health, Toxicology and Mutagenesis; Chemical Health and Safety
Abstract :
[en] Nitrous oxide (N2O) was originally used for medical and industrial purposes, but its recreational use has dramatically increased, raising a major global public health concern. Chronic inhalation is associated with neurological, metabolic, and psychiatric complications, as well as addiction. To address these challenges, the PROTOSIDE network was developed to provide a multidisciplinary approach to management and prevention. This initiative relies on competence centers integrating specialists in emergency medicine, neurology, clinical biochemistry, and addiction medicine. PROTOSIDE aims to standardize diagnostic protocols, optimize patient care pathways, and strengthen addictovigilance. A strong emphasis is placed on prevention, including awareness campaigns and collaboration with healthcare professionals and educators. By facilitating access to advanced biochemical analyses (homocysteine, methylmalonic acid) and promoting international guidelines, PROTOSIDE represents an innovative model for a global response to N2O misuse. This integrated approach enhances clinical management, reduces complications, and harmonizes public health strategies.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Grzych, Guillaume ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale ; CHU Lille, Service Biochimie Automatisée-Protéines, 59000 Lille, France
Diesnis, Remy ; Emergency Departement, CH Roubaix, 59100 Roubaix, France
Dupré, Thierry; Département de Biochimie, AP-HP, Hôpital Bichat, Biochimie, 75018 Paris, France
Niguet, Jean Paul; Service de Neurologie, Hôpital Saint Vincent de Paul-GHICL, 59000 Lille, France
Gernez, Emeline; CHU de Lille, Centre de Biologie Pathologie Génétique, 59000 Lille, France
Deheul, Sylvie; Inserm, UMR S1171, CHU Lille, Service de Pharmacologie Médicale, Université de Lille, 59000 Lille, France ; CEIP-Addictovigilance, Service de Pharmacologie Médicale, CHRU de Lille, 59045 Lille, France
Guichard, Jean Claude; Unité Sanitaire en Milieu Pénitentiaire USMP, 59000 Lille, France
Scliffet, Damien ; CH de Lens, Addictologie, 62300 Lens, France
Mégarbane, Bruno ; Réanimation Médicale et Toxicologique, Hôpital Lariboisière, Université Paris Cité, 75013 Paris, France
Boucher, Alexandra; Centre d'Addictovigilance, Hospices Civils de Lyon, 69000 Lyon, France
Bennis, Anas; Assistance Publique-Hôpitaux de Paris, Service de Neurologie, Groupe Hospitalier Universitaire Paris Sud, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France
Karila, Laurent; Centre d'Enseignement, de Recherche et de Traitement des Addictions, Hôpital Universitaire Paul-Brousse (AP-HP), Université Paris-Saclay, 94804 Villejuif, France
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Rolland, Benjamin; Service Universitaire d'Addictologie de Lyon (SUAL), Hospices Civils de Lyon, CH Le Vinatier, 69002 Lyon, France ; PSYR, CRNL, INSERM U1028, CNRS UMR5292, UCBL1, 69500 Lyon, France
Riou, Christophe; Service Universitaire d'Addictologie de Lyon (SUAL), Hospices Civils de Lyon, CH Le Vinatier, 69002 Lyon, France ; PSYR, CRNL, INSERM U1028, CNRS UMR5292, UCBL1, 69500 Lyon, France
Bossaert, Cécile ; CHU de Lille, Service des Urgences Adultes, SAMU, 59000 Lille, France
Chauvin, Anthony ; Emergency Department, Hôpital Lariboisière, APHP, 75010 Paris, France
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