[en] Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that an NAD-dependent glutamate dehydrogenase (GdhZ) coordinates growth with cell division according to its enzymatic activity. Here we report the conserved role of GdhZ in controlling cell division in another α-proteobacterium, the facultative intracellular pathogen Brucella abortus. We also discuss the importance of amino acids as a main carbon source for α-proteobacteria.
Beaufay, François ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP) ; Bacterial Cell cycle & Development (BCcD), URBM, University of Namur , Namur, Belgium
De Bolle, Xavier; Bacterial Cell cycle & Development (BCcD), URBM, University of Namur , Namur, Belgium
Hallez, Régis; Bacterial Cell cycle & Development (BCcD), URBM, University of Namur , Namur, Belgium
Language :
English
Title :
Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase.
Publication date :
2016
Journal title :
Communicative and Integrative Biology
eISSN :
1942-0889
Publisher :
Taylor and Francis Inc., Philadelphia, United States
F.B. held a FRIA (Fund for Research Training in Industry and Agriculture) fellowship from the National Fund for Scientific Research (F.R.S.-FNRS). R.H. is a FNRS Research Associate. This work was supported by a Research Project (PDR T.0053.13) to X.D.B and a Research Credit (CDR 1.5067.12) to R.H from the F.R.S.-FNRS.
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