Abstract :
[en] Cadmium chalcogenide quantum dots (CdX QDs,
X = S, Se, Te) are among the most extensively studied
semiconductor nanocrystals due to their size-tunable optical
properties and wide potential applications in optoelectronics,
bioimaging, and sensing. While early syntheses relied on hightemperature
organometallic routes in organic solvents, the demand
for safer, greener, and more biocompatible approaches has driven
increasing interest in aqueous-based methods. These two strategies
differ substantially in terms of precursor chemistry, surface
passivation, and control over nanocrystal quality. In parallel,
continuous flow technology has brought transformative assets to
the field, offering precise reaction control, scalability, and
reproducibility, which are essential for both fundamental studies
and industrial translation. This review summarizes the evolution of CdX QDs synthesis, contrasting organic and aqueous batch
approaches, and focuses on recent advances in aqueous continuous flow strategies. Finally, we highlight perspectives on the
integration of automated machine learning and artificial intelligence approaches with continuous flow, which may accelerate the
discovery, optimization, and scalable production of high-quality QDs for next-generation technologies.
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