Article (Scientific journals)
Three-dimensional echocardiographic assessments of exercise-induced changes in left ventricular shape and dyssynchrony in patients with dynamic functional mitral regurgitation.
Izumo, Mazaki; LANCELLOTTI, Patrizio; Suzuki, Kengo et al.
2009In European Journal of Echocardiography, 10 (8), p. 961-7
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Keywords :
Left ventricular dyssynchrony; Mitral regurgitation; Exercise; 3D echocardiography
Abstract :
[en] Aims: Left ventricular (LV) shape and LV dyssynchrony are two cofactors associated with functional mitral regurgitation (MR) in patients with heart failure. Both can be accurately examined by real-time three-dimensional echocardiography (3DE). We examined the relationship between dynamic MR and exercise-induced changes in LV shape and synchronicity using 3DE. Methods and results: Fifty patients with systolic LV dysfunction underwent 2D and 3D quantitative assessment of LV function, shape, and synchronicity at rest and during symptom-limited exercise test. According to the magnitude of change in MR, patients were divided into EMR group (15 patients, 30%), if the degree of MR increased during test, and NEMR group. During exercise, the changes in LV volumes and ejection fraction were similar in both groups, whereas changes in mitral valvular deformation parameters, in LV sphericity index, and in the extent of LV dyssynchrony were more pronounced in the EMR group. At rest, only the 3D sphericity index could distinguish the two groups. By stepwise multiple regression model, dynamic changes in the systolic dyssynchrony index, sphericity index, and coaptation distance were associated with dynamic MR (r2 = 0.45, P = 0.012). Conclusion: Dynamic MR during exercise is related to the 3D changes in LV shape and in LV synchronicity.
Disciplines :
General & internal medicine
Author, co-author :
Izumo, Mazaki
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Suzuki, Kengo
Kou, Seisyou
Shimozato, Takashi
Hayashi, Akio
Akashi, Yoshihiro J.
Osada, Naohiko
Omiya, Kazuto
Nobuoka, Sachihiko
Ohtaki, Eiji
Miyake, Fumihiko
Language :
English
Title :
Three-dimensional echocardiographic assessments of exercise-induced changes in left ventricular shape and dyssynchrony in patients with dynamic functional mitral regurgitation.
Publication date :
December 2009
Journal title :
European Journal of Echocardiography
ISSN :
1525-2167
eISSN :
1532-2114
Publisher :
Harcourt Publishers Limited
Volume :
10
Issue :
8
Pages :
961-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 February 2010

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