[en] This work reports a straightforward synthesis of macroporous polyHIPEs with antibacterial properties using (meth)acrylated derivatives of eugenol, thymol, soybean oil (AESO) and natural dyes. The approach relies on the intrinsic antibacterial activity expected from eugenol and thymol, together with the possible photoinduced antibacterial effects imparted by natural dyes. Such a strategy may provide porous bio-based materials in which both inherent and light-activated antibacterial mechanisms can be exploited. All polyHIPEs prepared from different dyes and monomers by emulsion templating process displayed comparable interconnected porous structures. The influence of dyes and monomer composition on thermal and mechanical properties was assessed using differential scanning calorimetry and dynamic mechanical analysis. Incorporation of natural dyes resulted in a decrease of the Young modulus and an increase of the glass transition temperature of the materials. The antibacterial properties of the photosensitive polyHIPEs containing natural dyes were compared with the pristine eugenol-, thymol- and AESO-based polyHIPEs, both under visible light exposure and in the dark. Despite the production of reactive oxygen species, irradiation of the photosensitive polyHIPEs associating natural dyes and essential oil monomers do not enhance antibacterial properties of the matrices. On the contrary, dye-free polyHIPEs based on eugenol or thymol showed strong inhibition of S. aureus adhesion and proliferation. These findings open new perspectives for the development of the next generation of antibacterial porous materials, with potential application in water depollution.
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Hayek, Hassan; University Paris-Est Créteil [UPEC] - CNRS - ICMPE - Thiais - France
Boucq, Pascal ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium
Andaloussi, Samir abbad; University Paris-Est Créteil [UPEC] - Laboratoire Eau, Environnement, SysTèmes Urbains [LEESU] - France
Kovačič, Sebastijan; University of Maribor - Faculty of Chemistry and Chemical Engineering - Slovenia ; National Institute of Chemistry - Ljubljana - Slovenia
Debuigne, Antoine ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium
Versace, Davy-Louis ; University Paris-Est Créteil [UPEC] - CNRS - ICMPE - Thiais - France
F.R.S.-FNRS - Fund for Scientific Research Ministère de l'Enseignement supérieur et de la Recherche Scientifique CNRS - Centre National de la Recherche Scientifique
Funding text :
This work was supported by the Ministere de l'Enseignement Sup\u00E9rieur et de la Recherche, the CNRS and the Universit\u00E9 Paris-Est Cr\u00E9teil (UPEC). A. Debuigne and P. Boucq are grateful to the F.R.S.-FNRS for financial support.
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