[en] [en] OBJECTIVE: This study aimed to provide an overview of the relationship between osteoarthritis (OA) pain and various fluid biomarkers by conducting a systematic literature review (SLR), to help the development of OA-related pain endotyping.
METHOD: An SLR was conducted, using the PubMed, Embase, Scopus, Web of Science and the Cochrane Library databases, up to December 2024. Pain measures (VAS, WOMAC, HOOS/KOOS, AUSCAN, PainDETECT and Pain Pressure Threshold) were analysed for their association with circulating biomarkers in blood, urine, synovial and cerebrospinal fluids or tissue and genetic biomarkers. Biomarkers were categorised as "associated" depending on statistical significance and further subcategorised as "consistently associated", "uncertainly associated" or "not associated" based on the quality of evidence determined by the number of studies, sample size and the strength of correlation.
RESULTS: The five databases yielded 30,088 citations, of which 263 relevant papers were selected. Total cholesterol in the blood was the only biomarker consistently associated with pain. Among blood biomarkers, CRP, hsCRP and IL-17 showed suggestive but inconsistent associations with OA-related pain. In synovial fluid, IL-17, C2C and VEGF were consistently associated with increasing pain intensity, based on multiple concordant studies. In cerebrospinal fluid, CX3CL1 and Flt-1 were consistently associated with pain, displaying a negative correlation.
CONCLUSION: This SLR identified no relevant biomarkers in different body fluids that were associated with OA-related pain. Further investigation of CRP and IL-17 is required to achieve greater consistency across studies.
PROSPERO: CRD42024550244.
Disciplines :
Rheumatology
Author, co-author :
Mathieu, Sylvain; Université Clermont Auvergne, Service de Rhumatologie, CHU Clermont-Ferrand, INSERM, Neuro-Dol, 63000, Clermont-Ferrand, France
Kuhi, Liisa; Central Laboratory, East Tallinn Central Hospital, Tallinn, Estonia
Binvignat, Marie; Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
Conaghan, Philip G; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Eijkelkamp, Niels; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
Henrotin, Yves ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Pathologie générale et physiopathologie - Techniques particulières de kinésithérapie ; Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium
Kosek, Eva; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm and Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Mobasheri, Ali; Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland ; State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania ; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Schaible, Hans-George; Institute of Physiology 1/Neurophysiology, Jena University Hospital, Friedrich-Schiller-University, D-07740, Jena, Germany
Kisand, Kalle; Department of Internal Medicine, Institute of Clinical Medicine, University of Tartu, Estonia
Sellam, Jérémie; Sorbonne Université Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Recherche Saint-Antoine (CRSA), Inserm UMRS-938, Paris, France
GO-PAIN working group
Language :
English
Title :
The relationship between circulating and tissue biomarkers and OA-related pain: A systematic literature review.
ANR - Agence Nationale de la Recherche Pfizer NIHR BRC - NIHR Imperial Biomedical Research Centre NIHR - National Institute for Health and Care Research
Funding text :
NEURON-ERA-NET (Network of European Funding for Neuroscience Research) and Association Fran\u00E7aise de Lutte Antirhumatismale (AFLAR). PGC is supported in part by the National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre (BRC) (NIHR203331). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.NEURON-ERA-NET (Network of European Funding for Neuroscience Research) and Agence Nationale de la Recherche that fund the 2022 Going Inside Osteoarthritis-Related Pain network (for organization and logistical requirements for the network).NEURON-ERA-NET (Network of European Funding for Neuroscience Research) and Agence Nationale de la Recherche that fund the 2022 Going Inside Osteoarthritis-Related Pain network (for organization and logistical requirements for the network).JS reports personal fees from MSD, Pfizer, Abbvie, Fresenius Kabi, BMS, Roche, Chugai, Sandoz, Lilly, Novartis, Galapagos, AstraZeneca, UCB, Gr\u00FCnenthal and Janssen and research grants from Pfizer, Schwa Medico, and BMS.NEURON-ERA-NET(Network of European Funding for Neuroscience Research) and Association Fran\u00E7aise de Lutte Antirhumatismale (AFLAR). PGC is supported in part by the National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre (BRC) (NIHR203331). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
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