Research priorities for physical activity and exercise management of people with knee and hip osteoarthritis: A multi-stage international priority-setting study from the OARSI Rehabilitation Discussion Group. - 2025
Research priorities for physical activity and exercise management of people with knee and hip osteoarthritis: A multi-stage international priority-setting study from the OARSI Rehabilitation Discussion Group.
Bennell, Kim L; Nelligan, Rachel K; Pardo, Jesse Jet al.
2025 • In Osteoarthritis and Cartilage, 33 (10), p. 1258 - 1267
[en] [en] OBJECTIVE: To identify research priorities for physical activity and exercise management of knee and hip osteoarthritis (OA).
DESIGN: We used a multi-stage process involving an international multi-disciplinary panel of 276 experts (150 consumers, 69 clinicians spanning 5 disciplines, 54 researchers, and 3 funder/consumer organisation representatives) from 26 countries. The process included: 1) compiling a list of unanswered research questions from existing research; 2) assembling the panel and generating additional questions from members via an online survey; 3) consolidating research questions (eg. removing duplicates); 4) scoring questions for priority by the panel on an 11-point numeric rating scale (0='not a priority at all; 10='highest priority') via another online survey; and 5) ranking the top 20 priority questions by the panel via an online discrete choice experiment (1000Minds).
RESULTS: A list of 61 research questions was compiled from the literature and the panel generated an additional 346 questions. Following consolidation, 178 questions remained and were scored by 150 of the original panelists (54%), with mean priority scores from 5.0 to 8.4. 153 (55%) panelists completed the discrete choice experiment. The top three research priorities were: 1) investigating the impact of physical activity and exercise on delaying/avoiding joint replacement, 2) developing effective interventions to promote long-term exercise adherence, and 3) stratifying people to the most appropriate form of exercise support.
CONCLUSION: We identified research priorities about physical activity and exercise management of knee and hip OA. These will guide the international research agenda with the aim of improving outcomes for people with OA.
Disciplines :
Orthopedics, rehabilitation & sports medicine
Author, co-author :
Bennell, Kim L ; Centre for Health, Exercise and Sports Medicine, University of Melbourne, Victoria, Australia. Electronic address: k.bennell@unimelb.edu.au
Nelligan, Rachel K ; Centre for Health, Exercise and Sports Medicine, University of Melbourne, Victoria, Australia. Electronic address: rachel.nelligan@unimelb.edu.au
Pardo, Jesse J ; Centre for Health, Exercise and Sports Medicine, University of Melbourne, Victoria, Australia. Electronic address: jesse.pardo@unimelb.edu.au
Stratulate, Sarah ; Centre for Health, Exercise and Sports Medicine, University of Melbourne, Victoria, Australia. Electronic address: sarah.stratulate@unimelb.edu.au
Holden, Melanie A ; School of Medicine, Keele University, Staffordshire, United Kingdom. Electronic address: m.holden@keele.ac.uk
Lawford, Belinda J ; Centre for Health, Exercise and Sports Medicine, University of Melbourne, Victoria, Australia. Electronic address: belinda.lawford@unimelb.edu.au
Thoma, Louise M ; Department of Health Sciences, The University of North Carolina at Chapel Hill, NC, United States. Electronic address: louise_thoma@med.unc.edu
White, Daniel K ; Department of Physical Therapy, University of Delaware, Delaware, United States. Electronic address: dkw@udel.edu
Wellsandt, Elizabeth ; Department of Health and Rehabilitation Sciences, University of Nebraska Medical Center, Nebraska, United States. Electronic address: elizabeth.wellsandt@unmc.edu
Master, Hiral ; Vanderbilt University Medical Center, Vanderbilt University, TN, United States. Electronic address: hiralmaster21@gmail.com
Larsen, Jesper Bie ; Department of Health Science and Technology, Aalborg University, Jutland, Denmark. Electronic address: jbl@hst.aau.dk
Button, Kate ; School of Healthcare Sciences, Cardiff University, Cardiff, United Kingdom. Electronic address: buttonk@cardiff.ac.uk
Collins, Natalie J ; School of Health and Rehabilitation Sciences, The University of Queensland, Queensland, Australia. Electronic address: n.collins1@uq.edu.au
Skou, Søren T ; The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Slagelse, Denmark, Center for Muscle and Joint Health, University of Southern Denmark, Odense, Denmark. Electronic address: stskou@health.sdu.dk
Henrotin, Yves ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Pathologie générale et physiopathologie - Techniques particulières de kinésithérapie
Hinman, Rana S ; Centre for Health, Exercise and Sports Medicine, University of Melbourne, Victoria, Australia. Electronic address: ranash@unimelb.edu.au
Research priorities for physical activity and exercise management of people with knee and hip osteoarthritis: A multi-stage international priority-setting study from the OARSI Rehabilitation Discussion Group.
NIH - National Institutes of Health NIGMS - National Institute of General Medical Sciences NHMRC - National Health and Medical Research Council ERC - European Research Council
Funding text :
The study was supported by a National Health and Medical Research Council Investigator grant (#1174431) at the Centre for Health, Exercise & Sports Medicine, University of Melbourne, Australia. The funder had no involvement in the: study design, collection, analysis and interpretation of data; writing of the manuscript; and decision to submit the manuscript for publication. RSH is supported by a NHMRC Investigator Grant (#2025733). RKN is supported by a University of Melbourne Sir Randal Heymanson Fellowship. BJL is supported by a University of Melbourne CR Roper Fellowship and Dame Kate Campbell Fellowship. STS is currently funded by a program grant from Region Zealand (Exercise First) and two grants from the European Union's Horizon 2020 research and innovation program, one from the European Research Council (MOBILIZE, grant agreement No 801790) and the other under grant agreement No 945377 (ESCAPE). EW is currently supported in part by the National Institute of General Medical Sciences (NIH U54 GM115458), which funds the Great Plains IDeA-CTR Network. For the purposes of open access, the authors have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.KLB has grant funding from the National Health and Medical Research Council, Medical Research Futures Fund and Medibank Private for exercise-related OA research. She consults for Sword Health and receives royalties from Wolters Kluwer. RSH has grant funding from the National Health and Medical Research Council, Medical Research Futures Fund and Medibank Private for exercise-related OA research. STS has received personal fees from Munksgaard, TrustMe-Ed, and Nestl\u00E9 Health Science, outside the submitted work, and is co-founder of GLA:D\u00AE, a not-for profit initiative hosted at University of Southern Denmark aimed at implementing clinical guidelines for osteoarthritis in clinical practice. EW has grant funding from the following: National Institutes of Health (NIH; R01AR080346; R15AG085105; R34AR083077); Arthritis Foundation Osteoarthritis Clinical Trials Network (OACTN) Clinical Trial Unit. NJC is a GLA:D\u00AE Australia trainer, and receives payment for her time to train GLA:D\u00AE practitioners. LMT has grant funding from the NIH (K23AR079037).The study was supported by a National Health and Medical Research Council Investigator grant (# 1174431 ) at the Centre for Health, Exercise & Sports Medicine, University of Melbourne , Australia. The funder had no involvement in the: study design, collection, analysis and interpretation of data; writing of the manuscript; and decision to submit the manuscript for publication. RSH is supported by a NHMRC Investigator Grant (# 2025733 ). RKN is supported by a University of Melbourne Sir Randal Heymanson Fellowship. BJL is supported by a University of Melbourne CR Roper Fellowship and Dame Kate Campbell Fellowship . STS is currently funded by a program grant from Region Zealand (Exercise First) and two grants from the European Union\u2019s Horizon 2020 research and innovation program, one from the European Research Council (MOBILIZE, grant agreement No 801790 ) and the other under grant agreement No 945377 (ESCAPE). EW is currently supported in part by the National Institute of General Medical Sciences (NIH U54 GM115458 ), which funds the Great Plains IDeA-CTR Network. For the purposes of open access, the authors have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
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