Prévalence des problèmes liés à la pharmacothérapie chez les patients hospitalisés suivis en période post-soins intensifs

ANDRE, Sébastien; Rousseau, Anne-Françoise; Seidel, Laurence; Albert, Adelin; Misset, Benoît; KOKOU, Manon; Gillet, Manon

doi:10.1016/j.phacli.2025.08.002

Article (Scientific journals)

Prévalence des problèmes liés à la pharmacothérapie chez les patients hospitalisés suivis en période post-soins intensifs

ANDRE, Sébastien; Rousseau, Anne-Françoise; Seidel, Laurence et al.

2025 • In Pharmacien Clinicien

Peer reviewed

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https://hdl.handle.net/2268/337674

DOI
10.1016/j.phacli.2025.08.002

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Keywords :

Drug-related problem; Healthcare quality improvement; Medication review; Pharmacist; Post-intensive care syndrome; Pharmacology (medical)

Abstract :

[en] Introduction: A stay in an intensive care unit (ICU) and the related transitions of care are at risk of drug-related problems (DRPs). However, DRPs in patients recently discharged from the ICU are still poorly studied, and post-ICU follow-up programs currently focus on the post-hospital period. The main objective of this prospective study was to describe the prevalence and the characteristics of DRPs in inpatients’ post-ICU drug treatments. Material and methods: Adults with an ICU stay ≥ 7 days enrolled in our post-ICU follow-up program between 15 November 2021 and 15 April 2022 were included in the study. In the general wards, the week following ICU discharge, a pharmacist conducted a full medication review, identified DRPs and delivered tailored interventions. Results: The treatments of 58 patients [74.1% men, age 62 (range: 33–84) years, ICU stay of 17 (7–95) days] were studied. In total, 302 DRPs (5 DRPs/patient) were identified among the drug treatments with all but one patient experiencing at least one DRP. Most DRPs occurred in the ICU (55.3%) and were related to treatment safety (54.3%). The main causes of DRPs were related to drug selection (46.6%) and prolonged treatment duration (17.0%). Based on identified DRPs, 306 pharmaceutical interventions were carried out and the predominant intervention was the withdrawal of a drug (43.8%). Patients with a greater number of prescribed drugs and a lower BMI were statistically more likely to have DRPs shortly after an extended ICU stay. Conclusions: The present study findings support early intervention in the post-ICU discharge period and suggest that selected patients may benefit more from medication management interventions.

Disciplines :

Anesthesia & intensive care
Pharmacy, pharmacology & toxicology

Author, co-author :

ANDRE, Sébastien ; Centre Hospitalier Universitaire de Liège - CHU > > Département de pharmacie hospitalière

Rousseau, Anne-Françoise ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Seidel, Laurence ; Université de Liège - ULiège > Département des sciences de la santé publique

Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique

Misset, Benoît ; Université de Liège - ULiège > Département des sciences cliniques

KOKOU, Manon ; Centre Hospitalier Universitaire de Liège - CHU > > Département de pharmacie hospitalière

Gillet, Manon ; Université de Liège - ULiège > Département de pharmacie

Language :

English

Title :

Prévalence des problèmes liés à la pharmacothérapie chez les patients hospitalisés suivis en période post-soins intensifs

Publication date :

2025

Journal title :

Pharmacien Clinicien

ISSN :

2772-9532

eISSN :

2772-9532

Publisher :

Elsevier Masson s.r.l.

Peer reviewed :

Peer reviewed

Additional URL :

https://api.elsevier.com/content/article/PII:S2772953225000887?httpAccept=text/xml

Funding text :

the authors thank all members of the post-ICU clinic of the University Hospital of Li\u00E8ge.

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since 19 November 2025

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