A Multicenter, Retrospective Analysis of Long-Term Survival in 255 Dogs With Pheochromocytoma Treated With Alpha-Adrenoreceptor Antagonists or Surgery (2010-2021). - 2025
A Multicenter, Retrospective Analysis of Long-Term Survival in 255 Dogs With Pheochromocytoma Treated With Alpha-Adrenoreceptor Antagonists or Surgery (2010-2021).
Steele, Matthew M E; van den Berg, Marit F; Galac, Saraet al.
2025 • In Journal of Veterinary Internal Medicine, 39 (5), p. 70220
[en] [en] BACKGROUND: The survival of dogs with pheochromocytoma (PCC) treated with adrenoreceptor antagonists has not been described or compared to surgically managed cases.
HYPOTHESIS/OBJECTIVES: The objective of this study is to evaluate the survival of medically and surgically managed dogs with PCC and investigate factors associated with survival.
ANIMALS: Two hundred fifty-five dogs with PCC, treated with alpha-adrenoreceptor antagonists (AA) without adrenalectomy (Group 1, n = 75), adrenalectomy +/- AA (Group 2, n = 128), or neither treatment (Group 3, n = 52).
METHODS: Retrospective, multicenter review of medical records. Median overall survival time (OST) for Groups 1 and 2 combined was calculated using Kaplan-Meier estimates, and then compared between Group 1 and Group 2 using Log-Rank testing. Cox proportional hazard analysis identified factors associated with survival in Groups 1 and 2 individually and combined.
RESULTS: Median OST for all cases was 854 (95% CI: 572-1136) days. Median OST was lower in Group 1 (247 days, 95% CI: 76-418 days) than in Group 2 (927 days, 95% CI: 587-1267 days; p < 0.001). In Group 2, 88/92 dogs (97.8%) that received presurgical AA treatment survived to discharge compared to 23/27 (85.2%) that did not receive AA pretreatment (p = 0.03). Lack of clinical signs at presentation was associated with increased survival in both groups combined (HR 0.5; 95% CI 0.3-0.9; p = 0.02) and in Group 2 alone (HR 0.3; 95% CI 0.1-0.7; p = 0.01).
CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with PCC treated with adrenalectomy have longer survival compared to those managed with AA without adrenalectomy.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Steele, Matthew M E ; ChesterGates Veterinary Specialists, Chester, UK ; Clinical Science and Services, Royal Veterinary College, London, UK
van den Berg, Marit F ; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Galac, Sara ; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
Dordio, Ana M; Davies Veterinary Specialists, Hitchin, UK
Threlfall, Anna; Davies Veterinary Specialists, Hitchin, UK
Gomes, Cláudia; Anderson Moores Veterinary Specialists, Winchester, UK ; The Queens Veterinary School Hospital, University of Cambridge, Cambridge, UK
Paul, Amanda; Anderson Moores Veterinary Specialists, Winchester, UK ; Hamilton Specialist Referrals, Wycombe, UK
Nolff, Mirja; Clinic for Small Animal Surgery, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
Sieber-Ruckstuhl, Nadja ; Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
Benchekroun, Ghita ; Ecole Nationale Vétérinaire d'Alfort, CHUVA, Unité de Médecine Interne, Maisons-Alfort, France
Allerton, Fergus; Willows Veterinary Specialists, Shirley, UK
Mendoza, Beatriz; North Downs Specialist Referrals, Bletchingley, UK
Spence, Susanna; North Downs Specialist Referrals, Bletchingley, UK ; London Vet Specialists, London, UK
Valiente, Paula; North Downs Specialist Referrals, Bletchingley, UK ; Veterinary Specialty Hospital of Hong Kong, Kowloon, People's Republic of China
Boag, Alisdair ; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK
Fracassi, Federico ; Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
Carranza Valencia, Alejandra ; Department of Clinical Veterinary Science, University of Bern, Bern, Switzerland
Pena-Ramos, Jorge ; Small Animal Referral Hospital, Langford Vets, University of Bristol, Bristol, UK
Lloyd-Bradley, Ben; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK ; Dick White Referrals, Cambridge, UK
Seth, Mayank; Dick White Referrals, Cambridge, UK ; Stansted Veterinary Specialists, Bishop's Stortford, UK
Fawsitt, Jack; The Queens Veterinary School Hospital, University of Cambridge, Cambridge, UK
Yu Foo, Fang; Anderson Moores Veterinary Specialists, Winchester, UK ; The Queens Veterinary School Hospital, University of Cambridge, Cambridge, UK
Heilmann, Romy M ; Faculty of Veterinary Medicine, Universität Leipzig, Leipzig, Germany
Silverstrini, Paolo ; Small Animal Teaching Hospital, University of Liverpool, Liverpool, UK ; Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lyssens, Aurélie ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée
Vangrinsven, Emilie; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
Casas-Acuna, Clara; Pride Veterinary Referrals, Derby, UK
Hrovat, Alenka; Pride Veterinary Referrals, Derby, UK
Mooney, Carmel T; University College Dublin Veterinary Hospital, Dublin, Republic of Ireland
Leal, Rodolfo O ; Centre for Interdisciplinary Research in Animal Health/Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal
Piekos, Karolina Maria; Eastcott Veterinary Referrals, Swindon, UK
Olivares, Gerard; Eastcott Veterinary Referrals, Swindon, UK
Ruiz, Guillame; Bristol Vet Specialists, Bristol, UK
Caulfield, Sarah J; Clinical Science and Services, Royal Veterinary College, London, UK ; Lumbray Park Veterinary Specialists, Alton, UK
Keyte, Sophie; Lumbray Park Veterinary Specialists, Alton, UK
Lamoureux, Anaïs ; Centre Hospitalier Vétérinaire Anicura Nordvet, La Madeleine, France
Scudder, Christopher J; Clinical Science and Services, Royal Veterinary College, London, UK
Gostelow, Ruth ; Clinical Science and Services, Royal Veterinary College, London, UK
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