Non-isocyanate polyurethanes: perspectives as biomaterials

[en] Polyurethanes (PUs) are used in many applications, including in the medical sector (e.g., breast implants, vascular access and cardiac assist devices) due to their remarkable mechanical performances combined with proven in vivo biocompatibility. However, their industrial synthesis from toxic isocyanate precursors poses environmental and health concerns. With regulations increasingly restricting the isocyanate use, exploring greener alternatives has become imperative. Extensive research of health-friendlier synthesis processes triggered the emergence of a new family of PUs called Non-Isocyanate Polyurethanes (NIPUs). Recent developments have shown that NIPUs are already competitive with PUs, for example in the adhesives and coatings field, and new opportunities emerged in biomedical applications. This review highlights recent breakthroughs regarding NIPUs development, emphasizing their appealing properties for biomedical applications as well as their biocompatibility. By shedding light on the close relationship between their peculiar structure and specific properties, we highlight the potential of NIPUs to engineer biomaterials and we position them as unprecedented options for the design of future medical devices.

Research Center/Unit :

GIGA Cardiovascular Sciences-Cardiology - ULiège [BE]
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège [BE]
CERM - Center for Education and Research on Macromolecules - ULiège [BE]

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Pierrard, Anna ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium

Ferreira Melo, Sofia ; University of Liège [ULiège] - GIGA - Cardiology - Belgium

Oury, Cécile ; University of Liège [ULiège] - GIGA - Cardiology - Belgium

Detrembleur, Christophe ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium > Walloon Excellence [ WEL] Research Institute - Wavre - Belgium

Jérôme, Christine ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium

Language :

English

Title :

Non-isocyanate polyurethanes: perspectives as biomaterials

Publication date :

13 June 2025

Journal title :

European Polymer Journal

ISSN :

0014-3057

eISSN :

1873-1945

Publisher :

Elsevier

Volume :

233

Pages :

113985

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fund for Scientific Research
Fondation Léon Fredericq

Funding text :

The authors would like to thank the “Fonds de la Recherche Scientifique” F.R.S.-FNRS in the frame of the FRIA project of S. F. Melo and the Research Director positions of C.D. and C.O.. S. F. Melo obtained additional financial support from the GIGA Doctoral School for Health Sciences and the “Fondation Léon Fredericq”

Available on ORBi :

since 02 August 2025

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