adherence; adolescents; allergic rhinitis; asthma; digital health; mHealth; real-world data; Humans; Young Adult; Adolescent; Cross-Sectional Studies; Research Design; Rhinitis; Rhinitis, Allergic; Asthma/drug therapy; Asthma/epidemiology; Pediatrics, Perinatology and Child Health; Immunology and Allergy; Immunology
Abstract :
[en] [en] BACKGROUND: In allergic rhinitis and asthma, adolescents and young adult patients are likely to differ from older patients. We compared adolescents, young adults and adults on symptoms, control levels, and medication adherence.
METHODS: In a cross-sectional study (2015-2022), we assessed European users of the MASK-air mHealth app of three age groups: adolescents (13-18 years), young adults (18-26 years), and adults (>26 years). We compared them on their reported rhinitis and asthma symptoms, use and adherence to rhinitis and asthma treatment and app adherence. Allergy symptoms and control were assessed by means of visual analogue scales (VASs) on rhinitis or asthma, the combined symptom-medication score (CSMS), and the electronic daily control score for asthma (e-DASTHMA). We built multivariable regression models to compare symptoms or medication accounting for potential differences in demographic characteristics and baseline severity.
RESULTS: We assessed 965 adolescent users (15,252 days), 4595 young adults (58,161 days), and 15,154 adult users (258,796 days). Users of all three age groups displayed similar app adherence. In multivariable models, age groups were not found to significantly differ in their adherence to rhinitis or asthma medication. These models also found that adolescents reported lower VAS on global allergy, ocular, and asthma symptoms (as well as lower CSMS) than young adults and adults.
CONCLUSIONS: Adolescents reported a better rhinitis and asthma control than young adults and adults, even though similar medication adherence levels were observed across age groups. These results pave the way for future studies on understanding how adolescents control their allergic diseases.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Sousa-Pinto, Bernardo; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Valiulis, Arunas; Interdisciplinary Research Group of Human Ecology, Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania ; European Academy of Paediatrics, (EAP/UEMS-SP), Brussels, Belgium
Melén, Erik ; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden ; Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden
Koppelman, Gerard H; Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, GRIACResearch Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Papadopoulos, Nikolaos G; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Makela, Mika; Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Haahtela, Tari; Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Bonini, Matteo; Department of Cardiovascular and Respiratory Sciences, Universita Cattolica del Sacro Cuore, Rome, Italy ; Department of Neurological, ENT and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli - IRCCS, Rome, Italy ; National Heart and Lung Institute (NHLI), Imperial College London, London, UK
Braido, Fulvio; Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy ; IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Brussino, Luisa; Department of Medical Sciences, University of Torino, Torino, Italy ; Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy
Cruz, Alvaro A; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil
Fiocchi, Alessandro ; Allergy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
Giovannini, Mattia ; Allergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy ; Department of Health Sciences, University of Florence, Florence, Italy
Gemicioglu, Bilun; Department of Pulmonary Diseases, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey
Kulus, Marek; Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland
Kuna, Piotr; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kupczyk, Maciej; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kvedariene, Violeta; Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania ; Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Larenas-Linnemann, Désirée E ; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Morais-Almeida, Mario; Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
Niedoszytko, Marek; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Ollert, Markus ; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg ; Department of Dermatology and Allergy Centre, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark
Pfaar, Oliver ; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Regateiro, Frederico S ; Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal ; Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine, University of Coimbra, Coimbra, Portugal ; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Roberts, Graham ; Faculty of Medicine, University of Southampton, Southampton, UK ; The David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, UK ; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Samolinski, Boleslaw; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
Savouré, Marine; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Villejuif, France ; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France
Taborda-Barata, Luis ; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal ; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal
Toppila-Salmi, Sanna; Department of Otorhinolaryngology, Kuopio University Hospital and University of Eastern Finland, Kupio, Finland ; Department of Allergy, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Ventura, Maria Teresa; Allergy and Clinical Immunology, University of Bari Medical School, Bari, Italy ; Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy
Vazquez-Ortiz, Marta; Section of Inflammation, Repair and Development, Imperial College London, National Heart and Lung Institute, London, UK ; Department of Paediatrics, Imperial College Healthcare NHS Trust, London, UK
Vieira, Rafael José; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Fonseca, Joao A; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS@RISE - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Yorgancioglu, Arzu; Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
Zuberbier, Torsten; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
Anto, Josep M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain ; Universitat Pompeu Fabra (UPF), Barcelona, Spain ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Bousquet, Jean ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany ; MASK-air, Montpellier, France
Pham-Thi, Nhân; Ecole Polytechnique de Palaiseau, Palaiseau, France ; IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France ; Université Paris Cité, Paris, France
None specific for this paper. MASK\u2010air has been supported by EU grants (from the Impact of air Pollution on Asthma and Rhinitis project of the European Institute of Innovation and Technology Health; Structural and Development Funds, R\u00E9gion Languedoc Roussillon, and Provence\u2010Alpes\u2010C\u00F4te d'Azur; Twinning, European Innovation Partnership on Active and Healthy Ageing, DG Sant\u00E9 and DG Connect; H2020 and Horizon Europe), and educational grants from Mylan\u2010Viatris, Allergologisk Laboratorium K\u00F8benhavn, GlaxoSmithKline, Novartis, Stallergenes and Uriach.
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