Co-enzyme Q10; Ketogenic diet; Magnesium; Migraine; Riboflavin; Economics, Econometrics and Finance (all); Business, Management and Accounting (all)
Abstract :
[en] Compelling evidence suggests that increased energetic demands combined to reduced supplies in the brain play a role in migraine pathophysiology and may lead to the disruption of cortical homeostasis that ignites headache attacks. Consistent with this concept, most conventional migraine preventives reduce cortical excitability, and thus neuronal demands, thereby restoring energetic equilibrium. However, these drugs often cause numerous side effects that lead to treatment discontinuation. Conversely, enhancing energetic supplies with nutraceuticals or diets similarly restores the energetic imbalance in the brain but, by maintaining normal neuronal functioning, is associated with a better tolerability profile. Nonetheless, most of these therapies are often undervalued due to their relatively limited supporting evidence compared to classical pharmacotherapies. In this chapter, we comprehensively review the evidence behind most metabolic-enhancing and substrate-based therapies, as well as the pharmacodynamics of the principal nutraceuticals used in migraine prevention. We conclude that several nutraceuticals, i.a. vitamins B2 and B9, are evidence-supported migraine preventives characterized by an excellent efficacy/adverse effect profile. They can be offered as first line preventive treatment to subgroups pf patients with low or moderate disability. Ketogenic diet can be useful for high frequency and chronic migraine.
Disciplines :
Neurology
Author, co-author :
Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Lisicki, Marco; Headache Research Laboratory, Mercedes & Martín Ferreyra Institute, National Scientific and Technical Research Council (CONICET), National University of Córdoba, Argentina ; Department of Biomedical Physics, School of Medicine, National University of Córdoba, Argentina
Language :
English
Title :
Nutraceuticals and diets
Publication date :
2024
Main work title :
Migraine Pain Management: Current Pharmacological and Non-pharmacological Options
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