Endocrine disrupting chemicals alter neuronal circuits controlling reproduction and appetite

Endocrine Disruptors; Endocrine Disruptors/toxicity/pharmacology/adverse effects; Humans; Reproduction/drug effects/physiology; Hypothalamus/drug effects; Animals; Appetite/drug effects; Female; Energy Metabolism/drug effects; Sexual Maturation/drug effects; Pregnancy; Energy balance; Hypothalamus; Obesity; Puberty; Reproduction

Abstract :

[en] Exposure to endocrine disrupting chemicals during critical periods of development can result in detrimental long-term health consequences. The hypothalamus is extremely sensitive to endocrine disrupting chemicals, which could participate to the increase in metabolic and reproduction related diseases. We propose the concept according to which exposure to low levels of endocrine disrupting chemicals induces developmental and transgenerational alterations of sexual maturation and energy balance through reprograming of the hypothalamus.

Disciplines :

Endocrinology, metabolism & nutrition
Pediatrics

Author, co-author :

Pinson, Anneline ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Neuroendocrinology

Glachet, Chloé ; Université de Liège - ULiège > GIGA

Jacquinet, Charlotte ; Université de Liège - ULiège > GIGA

Sevrin, Elena ; Université de Liège - ULiège > GIGA

Moralia, Marie-Azélie ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Parent, Anne-Simone ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Language :

English

Title :

Endocrine disrupting chemicals alter neuronal circuits controlling reproduction and appetite

Publication date :

June 2025

Journal title :

Annales d'Endocrinologie

ISSN :

0003-4266

eISSN :

2213-3941

Publisher :

Elsevier Masson, Paris, France

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 03 July 2025

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