Article (Scientific journals)
Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003-2007.
Detry, Olivier; Donckier, Vincent; Lucidi, Valerio et al.
2010In Transplant International, 23 (6), p. 611-618
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Keywords :
extended donor criteria; graft failure; graft outcome; non-heart beating donation; ischemic bile duct lesion
Abstract :
[en] The Belgian experience with donation after cardiac death (DCD) liver transplantation (LT) was retrospectively reviewed, particularly evaluating patient and graft survivals, and biliary complications. From 2003 to 2007, 58 DCD-LT were performed in Belgium. Mean procurement total warm ischemia time was 25 +/- 2 min (mean +/- SEM). Mean cold ischemia time was 451 +/- 18 min. Mean follow-up was 23 +/- 2.2 months. Post-transplant peak aspartate aminotransminases was 2241 +/- 338 UI/l. Patient survivals at 1 month, 1 and 3 years, were 91.3%, 83.3% and 66.9% respectively. Graft survivals at 1 month, 1 and 3 years, were 84.4%, 72.4% and 48.8% respectively. Two patients (3.4%) developed primary nonfunction. Regarding the biliary complications, seven grafts (12%) were lost because of intrahepatic cholangiopathy, and 12 other patients (20.6%) developed bile duct stenoses requiring endoscopic and/or surgical management. The rate of symptomatic ischemic biliary lesions for grafts surviving more than 3 months was 38% (19/50). Although DCD organ donors may be a source of viable liver grafts, results were inferior to those obtained with donation after brain death LT in this series. Prognostic criteria have to be developed to improve results of DCD-LT.
Disciplines :
Gastroenterology & hepatology
Surgery
Author, co-author :
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Donckier, Vincent
Lucidi, Valerio
Ysebaert, Dirk
Chapelle, Thierry
Lerut, Jan
Ciccarelli, Olga
Pirenne, Jacques
Monbaliu, Diethaard
De Roover, Arnaud ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Honore, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Rogiers, Xavier
De Hemptinne, Bernard
Troisi, Roberto
More authors (4 more) Less
Language :
English
Title :
Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003-2007.
Publication date :
June 2010
Journal title :
Transplant International
ISSN :
0934-0874
eISSN :
1432-2277
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
23
Issue :
6
Pages :
611-618
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 December 2009

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