ADL; Falls; Fractures; GLIS; Hospitalization; IADL; Mobility; Mortality; Muscle mass; Muscle strength; Nursing home admission; Outcomes; Physical performance; Quality of life; Sarcopenia; Humans; Activities of Daily Living; Consensus; Quality of Life; Leadership; Aged; Accidental Falls; Sarcopenia/diagnosis; Aging; Geriatrics and Gerontology
Abstract :
[en] The Global Leadership Initiative in Sarcopenia (GLIS) aims to standardize the definition and diagnostic criteria for sarcopenia into one unifying, common classification. Among other actions to achieve this objective, the GLIS has organized three different working groups (WGs), with the WG on outcomes of sarcopenia focusing on reporting its health outcomes to be measured in clinical practice once a diagnosis has been established. This includes sarcopenia definitions that better predict health outcomes, the preferred tools for measuring these outcomes, and the cutoffs defining normal and abnormal values. The present article synthesizes discussions and conclusions from this WG, composed of 13 key opinion leaders from different continents worldwide. Results rely on systematic reviews, meta-analyses, and relevant cohort studies in the field. With a high level of evidence, sarcopenia is significantly associated with a reduced quality of life, a higher risk of falls and fractures and a higher risk of mortality. Sarcopenia has been moderately associated with a higher risk of reduced instrumental activities of daily living (IADL). However, the GLIS WG found only inconclusive level of evidence to support associations between sarcopenia and higher risks of hospitalization, nursing home admission, mobility impairments, and reduced basic activities of daily living (ADL). This limitation underscores the scarcity of longitudinal studies, highlighting a barrier to understanding its progression and implications over time.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Beaudart, Charlotte ; Public Health Aging Research & Epidemiology (PHARE) Group, Research Unit in Clinical, Pharmacology and Toxicology (URPC), Faculty of Medicine, NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium. charlotte.beaudart@unamur.be
Alcazar, Julian; GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain ; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain ; Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Toledo, Spain
Aprahamian, Ivan; Division of Geriatrics, Department of Internal Medicine, Jundiaí Medical School, Jundiaí, Brazil
Batsis, John A; Division of Geriatric Medicine, School of Medicine, and the Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA
Yamada, Yosuke; Department of Medicine and Science in Sports and Exercise, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan ; Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi, 980-8575, Japan
Prado, Carla M; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique ; Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
Sanchez-Rodriguez, Dolores; Rehabilitation Research Group, Hospital del Mar Medical Research Institute, 08003, Barcelona, Spain ; Geriatrics Department, Brugmann University Hospital, Université Libre de Bruxelles, 1020, Brussels, Belgium ; Geriatrics Department, Hospital Del Mar, Hospital de L'Esperança, Centre Fòrum, Parc de Salut Mar, 08029, Barcelona, Spain
Lim, Wee Shiong; Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore ; Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore
Sim, Marc; School of Medical and Health Sciences, Nutrition and Health Innovation Research Institute, Edith Cowan University, Joondalup, WA, Australia ; Medical School, University of Western Australia, Crawley, WA, Australia
von Haehling, Stephan; Department of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany ; German Center for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany
Woo, Jean; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Duque, Gustavo; Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, BoneMontreal, QC, Canada ; Dr. Joseph Kaufmann Chair in Geriatric Medicine, Department of Medicine, McGill University, Montreal, QC, Canada
Global Leadership Initiative in Sarcopenia (GLIS) group
J.A.B.\u2019s work is partially supported by the National Institute of Aging of the National Institute of Health grant number R01 AG071663 and P30DK056350-23. JA\u2019s work was partially supported by CIBERFES (CB16/10/00477), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovaci\u00F3n, and Uni\u00F3n Europea (European Regional Development Fund). None funding received for this particular work.
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