[en] [en] BACKGROUND: The study of the cortical functional network properties in schizophrenia (SZ) may benefit from the use of graph theory parameters applied to high-density electroencephalography (EEG). Connectivity Strength (CS) assesses global synchrony of the network, and Shannon Graph Complexity (SGC) summarizes the network distribution of link weights and allows distinguishing between primary and secondary pathways. Their joint use may help in understanding the underpinnings of the functional network hyperactivation and task-related hypomodulation previously described in psychoses.
METHODS: We used 64-sensor EEG recordings during a P300 oddball task in 128 SZ patients (96 chronic, CR, and 32 first episodes, FE), as well as 46 bipolar disorder (BD) patients, and 92 healthy controls (HC). Pre-stimulus and modulation (task-response minus pre-stimulus windows values) of CS and SGC were assessed in the theta band (4-8 Hz) and the broadband (4-70 Hz).
RESULTS: Compared to HC, SZ patients (CR and FE) showed significantly higher pre-stimulus CS values in the broadband, and both SZ and BD patients showed lower theta-band CS modulation. SGC modulation values, both theta-band and broadband, were also abnormally reduced in CR patients. Statistically significant relationships were found in the theta band between SGC modulation and both CS pre-stimulus and modulation values in patients. CS altered measures in patients were additionally related to their cognitive outcome and negative symptoms. A primary role of antipsychotics in these results was ruled out.
CONCLUSIONS: Our results linking SGC and CS alterations in psychotic patients supported a hyperactive and hypomodulatory network mainly involving connections in secondary pathways.
Disciplines :
Psychiatry
Author, co-author :
Díez, Álvaro; Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain
Gomez-Pilar, Javier; Biomedical Engineering Group, University of Valladolid, Valladolid, Spain., CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Valladolid, Spain
Poza, Jesús; Biomedical Engineering Group, University of Valladolid, Valladolid, Spain., CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Valladolid, Spain
Beño-Ruiz-de-la-Sierra, Rosa; Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain
Fernández-Linsenbarth, Inés; Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain
Nunez Novo, Pablo ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Coma Science Group
Holgado-Madera, Pedro; Psychiatry Service, 12 de Octubre Hospital, Madrid, Spain
Molina, Vicente; Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain., Psychiatry Service, Clinical University Hospital of Valladolid, Valladolid, Spain.. Electronic address: vicente.molina@uva.es
Language :
English
Title :
Functional network properties in schizophrenia and bipolar disorder assessed with high-density electroencephalography.
Publication date :
08 February 2024
Journal title :
Progress in Neuro-Psychopharmacology and Biological Psychiatry
This work was supported by the following grants: ‘ Instituto de Salud Carlos III ’ ( PI-22/0046 5), and ‘ Gerencia Regional de Salud de Castilla y León ’ ( GRS-2487/A/22 ). Two research training grants by the ‘ Consejería de Educación – Junta de Castilla y León ’ and the ‘ European Social Fund ’ ( VA-223-19 and VA-183-18 ) were respectively awarded to PhD candidates RBRS and IFL. These funding sources had no other role than that of providers of financial support.
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