[en] Automated behavior analysis are promising tools to overcome current assessment limitations in psychiatry. At 9 months of age, we recorded 32 infants with West syndrome (WS) and 19 typically developing (TD) controls during a standardized mother-infant interaction. We computed infant hand movements (HM), speech turn taking of both partners (vocalization, pause, silences, overlap) and motherese. Then, we assessed whether multimodal social signals and interactional synchrony at 9 months could predict outcomes (autism spectrum disorder (ASD) and intellectual disability (ID)) of infants with WS at 4 years. At follow-up, 10 infants developed ASD/ID (WS+). The best machine learning reached 76.47% accuracy classifying WS vs. TD and 81.25% accuracy classifying WS+ vs. WS-. The 10 best features to distinguish WS+ and WS- included a combination of infant vocalizations and HM features combined with synchrony vocalization features. These data indicate that behavioral and interaction imaging was able to predict ASD/ID in high-risk children with WS.
Disciplines :
Psychiatry
Author, co-author :
Ouss, Lisa ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie infanto-juvénile ; Service de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
Palestra, Giuseppe ; Institut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Saint-Georges, Catherine; Institut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France. ; Département de Psychiatrie de l'Enfant et de l'Adolescent, AP-HP, Hôpital Pitié-Salpêtrière, 47-83, Boulevard de l'Hôpital, 75651, Paris, Cedex 13, France.
Leitgel Gille, Marluce; Service de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
Afshar, Mohamed; Ariana Pharmaceuticals, Research Department, Paris, France.
Pellerin, Hugues; Institut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Bailly, Kevin; Institut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Chetouani, Mohamed; Institut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Robel, Laurence; Service de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
Golse, Bernard; Service de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
Nabbout, Rima; Service de Neuropédiatrie, AP-HP, Hôpital Necker, 136, Rue de Vaugirard, 75015, Paris, France.
Desguerre, Isabelle; Service de Neuropédiatrie, AP-HP, Hôpital Necker, 136, Rue de Vaugirard, 75015, Paris, France.
Guergova-Kuras, Mariana; Ariana Pharmaceuticals, Research Department, Paris, France.
Cohen, David ; Institut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France. david.cohen@aphp.fr. ; Département de Psychiatrie de l'Enfant et de l'Adolescent, AP-HP, Hôpital Pitié-Salpêtrière, 47-83, Boulevard de l'Hôpital, 75651, Paris, Cedex 13, France. david.cohen@aphp.fr.
Behavior and interaction imaging at 9 months of age predict autism/intellectual disability in high-risk infants with West syndrome.
Publication date :
03 February 2020
Journal title :
Translational Psychiatry
eISSN :
2158-3188
Publisher :
Springer, New-York, Us ny
Volume :
10
Issue :
1
Pages :
54
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
ANR-12-SAMA-006-1/Agence Nationale de la Recherche (French National Research Agency)/International; ANR- 11-LABX-65/Agence Nationale de la Recherche (French National Research Agency)/International; ANR-11-IDEX-0004-02/Agence Nationale de la Recherche (French National Research Agency)/International
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