Peripheral arterial disease; guidelines; management; training
Abstract :
[en] The new guidelines for the management of peripheral arterial and aortic diseases (PAAD) from the European Society of Cardiology and endorsed by the European Society of Vascular Medicine (ESVM), emphasize on a comprehensive and multidisciplinary approach focusing on prevention, diagnosis, treatment, and follow-up of patients with a wide range of PAAD, including lower extremity peripheral arterial disease (PAD). The aim of this summary, focusing on PAD and coordinated by the Young Academy of ESVM, is to provide young angiologists with the fundamental principles of these guidelines and to assist them in navigating their everyday clinical practice. PAD diagnosis relies on objective evaluation of flow/oxygen reduction at rest, with arterial ultrasound as the first imaging modality to confirm the presence of arterial lesions. The main goals of PAD management are not only to improve functioning and prevent the occurrence of adverse events at the lower limb level, but also to reduce the overall atherosclerotic burden and achieve the general well-being of patients. To this end, traditional and nontraditional cardiovascular risk factors need to be properly addressed through lifestyle changes and tailored drug therapies. For patients with exertional limb symptoms, supervised exercise training is recommended. Interventional treatment is indicated for limb salvage in patients with chronic limb threatening ischemia and may also be discussed in a multidisciplinary setting in less severe patients with persisting symptoms and reduced quality of life after a minimum period of optimal medical treatment including exercise therapy. For trainees or young specialists in Angiology/Vascular Medicine, these guidelines provide essential elements to improve patient management, encourage interdisciplinary collaboration, and ensure an integrated approach to vascular diseases.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Buso, Giacomo ; Department of Clinical and Experimental Sciences, Division of Internal Medicine, ASST Spedali Civili Brescia, University of Brescia, Italy ; University of Lausanne, Switzerland
Hersant, Jeanne ; Department of Vascular Medicine, University Hospital of Angers, France
Keller, Sanjiv ; Angiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, Switzerland
Kalaja, Igli ; Department for Cardiology III - Angiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Bigolin, Paola ; Angiology Unit, Azienda ULSS 2 Marca Trevigiana, Castelfranco Veneto, Italy
Porceddu, Enrica; Angiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, Switzerland
Ghirardini, Francesca; Angiology Unit, AULSS 1 Dolomiti, San Martino Hospital, Belluno, Italy
Novaković, Marko ; Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia
Meilak, Darren Galea; Vascular Unit, Mater Dei Hospital, Malta
Džupina, Andrej; Department of Cardiology and Angiology, National Institute of Cardiovascular Diseases, Bratislava, Slovakia
Gary, Thomas; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Austria
Bura-Rivière, Alessandra; Department of Vascular Medicine, Toulouse University Hospital, France ; Department of Medicine, Faculté de Santé Université Toulouse III, France
Heiss, Christian ; Vascular Department, Surrey and Sussex Healthcare NHS Trust, East Surrey Hospital, Redhill, UK ; Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Lanzi, Stefano ; Angiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, Switzerland
Madaric, Juraj ; Department of Angiology, Comenius University and National Institute of Cardiovascular Diseases, Bratislava, Slovakia
Boc, Vinko ; Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia ; Department of Internal Medicine, Faculty of Medicine, University of Ljubljana, Slovenia
Sprynger, Muriel ; Université de Liège - ULiège > Département des sciences cliniques
Mirault, Tristan; Université Paris Cité, PARCC Inserm U970, CRMR MARS, VASCERN, Vascular Medicine, Hôpital Européen Georges-Pompidou APHP, Paris, France
Brodmann, Marianne; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Austria
Schlager, Oliver ; Division of Angiology, Department of Medicine II, Medical University of Vienna, Austria
Mazzolai, Lucia; Angiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, Switzerland
Collaborators GBDPAD. Global burden of peripheral artery disease and its risk factors, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Glob Health. 2023; 11: e1553-e1565.
Eid MA, Mehta K, Barnes JA, Wanken Z, Columbo JA, Stone DH, et al. The global burden of peripheral artery disease. J Vasc Surg. 2023; 77: 1119-1126.e1.
Hageman SHJ, de Borst GJ, Dorresteijn JAN, Bots ML, Westerink J, Asselbergs FW, et al. Cardiovascular risk factors and the risk of major adverse limb events in patients with symptomatic cardiovascular disease. Heart. 2020; 106: 1686-1692.
Anand SS, Caron F, Eikelboom JW, Bosch J, Dyal L, Aboyans V, et al. Major adverse limb events and mortality in patients with peripheral artery disease: The COMPASS trial. J Am Coll Cardiol. 2018; 71: 2306-2315.
Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, et al. 2024 ESC guidelines for the management of peripheral arterial and aortic diseases. Eur Heart J. 2024; 45: 3538-3700.
Lin J, Chen Y, Jiang N, Li Z, Xu S. Burden of peripheral artery disease and its attributable risk factors in 204 countries and territories from 1990 to 2019. Front Cardiovasc Med. 2022; 9: 868370.
Lindholt JS, Sogaard R. Clinical benefit, harm, and cost effectiveness of screening men for peripheral artery disease: A Markov model based on the VIVA trial. Eur J Vasc Endovasc Surg. 2021; 61: 971-979.
Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: A systematic review and analysis. Lancet. 2013; 382: 1329-1340.
Eraso LH, Fukaya E, Mohler ER 3rd, Xie D, Sha D, Berger JS. Peripheral arterial disease, prevalence and cumulative risk factor profile analysis. Eur J Prev Cardiol. 2014; 21: 704-711.
Sigvant B, Lundin F, Wahlberg E. The risk of disease progression in peripheral arterial disease is higher than expected: A meta-Analysis of mortality and disease progression in peripheral arterial disease. Eur J Vasc Endovasc Surg. 2016; 51: 395-403.
Kaplovitch E, Eikelboom JW, Dyal L, Aboyans V, Abola MT, Verhamme P, et al. Rivaroxaban and aspirin in patients with symptomatic lower extremity peripheral artery disease: A subanalysis of the COMPASS randomized clinical trial. JAMA Cardiol. 2021; 6: 21-29.
Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O, et al. Rivaroxaban with or without aspirin in stable cardiovascular disease. N Engl J Med. 2017; 377: 1319-1330.
Hiatt WR, Fowkes FG, Heizer G, Berger JS, Baumgartner I, Held P, et al. Ticagrelor versus clopidogrel in symptomatic peripheral artery disease. N Engl J Med. 2017; 376: 32-40.
Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000. Circulation. 2004; 110: 738-743.
McDermott MM, Mehta S, Greenland P. Exertional leg symptoms other than intermittent claudication are common in peripheral arterial disease. Arch Intern Med. 1999; 159: 387-392.
Mahe G, Boge G, Bura-Riviere A, Chakfe N, Constans J, Goueffic Y, et al. Disparities between international guidelines (AHA/ESC/ESVS/ESVM/SVS) concerning lower extremity arterial disease: Consensus of the French Society of Vascular Medicine (SFMV) and the French Society for Vascular and Endovascular Surgery (SCVE). Ann Vasc Surg. 2021; 72: 1-56.
Aboyans V, Criqui MH, Abraham P, Allison MA, Creager MA, Diehm C, et al. Measurement and interpretation of the ankle-brachial index: A scientific statement from the American Heart Association. Circulation. 2012; 126: 2890-2909.
Porras CP, Bots ML, Teraa M, van Doorn S, Vernooij RWM. Differences in symptom presentation in women and men with confirmed lower limb peripheral artery disease: A systematic review and meta-Analysis. Eur J Vasc Endovasc Surg. 2022; 63: 602-612.
Stoffers HE, Kester AD, Kaiser V, Rinkens PE, Kitslaar PJ, Knottnerus JA. The diagnostic value of the measurement of the ankle-brachial systolic pressure index in primary health care. J Clin Epidemiol. 1996; 49: 1401-1405.
Laing S, Greenhalgh RM. The detection and progression of asymptomatic peripheral arterial disease. Br J Surg. 1983; 70: 628-630.
Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, Byrd L, et al. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS guideline for the management of lower extremity peripheral artery disease: A report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2024; 149: e1313-e1410.
Ankle Brachial Index C, Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: A meta-Analysis. JAMA. 2008; 300: 197-208.
Fowkes FG, Murray GD, Butcher I, Folsom AR, Hirsch AT, Couper DJ, et al. Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. Eur J Prev Cardiol. 2014; 21: 310-320.
Tehan PE, Santos D, Chuter VH. A systematic review of the sensitivity and specificity of the toe-brachial index for detecting peripheral artery disease. Vasc Med. 2016; 21: 382-389.
Rodway AD, Cheal D, Allan C, Pazos-Casal F, Hanna L, Field BCT, et al. Ankle doppler for cuffless ankle brachial index estimation and peripheral artery disease diagnosis independent of diabetes. J Clin Med. 2022; 12 (1): 97.
Katsanos K, Tepe G, Tsetis D, Fanelli F. Standards of practice for superficial femoral and popliteal artery angioplasty and stenting. Cardiovasc Intervent Radiol. 2014; 37: 592-603.
Gardner AW, Montgomery PS, Ritti-Dias RM, Forrester L. The effect of claudication pain on temporal and spatial gait measures during self-paced ambulation. Vasc Med. 2010; 15: 21-26.
Koutakis P, Johanning JM, Haynatzki GR, Myers SA, Stergiou N, Longo GM, et al. Abnormal joint powers before and after the onset of claudication symptoms. J Vasc Surg. 2010; 52: 340-347.
McDermott MM, Liu K, Greenland P, Guralnik JM, Criqui MH, Chan C, et al. Functional decline in peripheral arterial disease: Associations with the ankle brachial index and leg symptoms. JAMA. 2004; 292: 453-461.
Raja A, Spertus J, Yeh RW, Secemsky EA. Assessing health-related quality of life among patients with peripheral artery disease: A review of the literature and focus on patient-reported outcome measures. Vasc Med. 2021; 26: 317-325.
Schieber MN, Hasenkamp RM, Pipinos II, Johanning JM, Stergiou N, DeSpiegelaere HK, et al. Muscle strength and control characteristics are altered by peripheral artery disease. J Vasc Surg. 2017; 66: 178-186.
Gardner AW, Montgomery PS. Impaired balance and higher prevalence of falls in subjects with intermittent claudication. J Gerontol A Biol Sci Med Sci. 2001; 56: M454-M458.
McDermott MM, Tian L, Liu K, Guralnik JM, Ferrucci L, Tan J, et al. Prognostic value of functional performance for mortality in patients with peripheral artery disease. J Am Coll Cardiol. 2008; 51: 1482-1489.
Golledge J, Leicht AS, Yip L, Rowbotham SE, Pinchbeck J, Jenkins JS, et al. Relationship between disease specific quality of life measures, physical performance, and activity in people with intermittent claudication caused by peripheral artery disease. Eur J Vasc Endovasc Surg. 2020; 59: 957-964.
Conijn AP, Jens S, Terwee CB, Breek JC, Koelemay MJ. Assessing the quality of available patient reported outcome measures for intermittent claudication: A systematic review using the COSMIN checklist. Eur J Vasc Endovasc Surg. 2015; 49: 316-334.
Rymer JA, Narcisse D, Cosiano M, Tanaka J, McDermott MM, Treat-Jacobson DJ, et al. Patient-reported outcome measures in symptomatic, non-limb-Threatening peripheral artery disease: A state-of-The-Art review. Circ Cardiovasc Interv. 2022; 15: e011320.
Hays RD, Sherbourne CD, Mazel RM, ND RA. The RAND 36-Item Health Survey 1.0. Health Econ. 1993; 2: 217-227.
Criqui MH, Denenberg JO, Bird CE, Fronek A, Klauber MR, Langer RD. The correlation between symptoms and non-invasive test results in patients referred for peripheral arterial disease testing. Vasc Med. 1996; 1: 65-71.
Hirsch AT, Criqui MH, Treat-Jacobson D, Regensteiner JG, Creager MA, Olin JW, et al. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA. 2001; 286: 1317-1324.
Morgan MB, Crayford T, Murrin B, Fraser SC. Developing the vascular quality of life questionnaire: A new disease-specific quality of life measure for use in lower limb ischemia. J Vasc Surg. 2001; 33: 679-687.
Hiatt WR, Rogers RK, Brass EP. The treadmill is a better functional test than the 6-minute walk test in therapeutic trials of patients with peripheral artery disease. Circulation. 2014; 130: 69-78.
Mazzolai L, Belch J, Venermo M, Aboyans V, Brodmann M, Bura-Riviere A, et al. Exercise therapy for chronic symptomatic peripheral artery disease. Eur Heart J. 2024; 45: 1303-1321.
McDermott MM, Guralnik JM, Criqui MH, Liu K, Kibbe MR, Ferrucci L. Six-minute walk is a better outcome measure than treadmill walking tests in therapeutic trials of patients with peripheral artery disease. Circulation. 2014; 130: 61-68.
Lanzi S, Calanca L, Berchtold A, Mazzolai L. Improvement in 6-minute walking distance after supervised exercise training is related to changes in quality of life in patients with lower extremity peripheral artery disease. J Clin Med. 2021; 10 (15): 3330.
Matsushita K, Gao Y, Sang Y, Ballew SH, Salameh M, Allison M, et al. Comparative mortality according to peripheral artery disease and coronary heart disease/stroke in the United States. Atherosclerosis. 2022; 354: 57-62.
Abtan J, Bhatt DL, Elbez Y, Sorbets E, Eagle K, Reid CM, et al. Geographic variation and risk factors for systemic and limb ischemic events in patients with symptomatic peripheral artery disease: Insights from the REACH Registry. Clin Cardiol. 2017; 40: 710-718.
Weissler EH, Jones WS, Desormais I, Debus S, Mazzolai L, Espinola-Klein C, et al. Polyvascular disease: A narrative review of current evidence and a consideration of the role of antithrombotic therapy. Atherosclerosis. 2020; 315: 10-17.
Feldman DN, Armstrong EJ, Aronow HD, Gigliotti OS, Jaff MR, Klein AJ, et al. SCAI consensus guidelines for device selection in femoral-popliteal arterial interventions. Catheter Cardiovasc Interv. 2018; 92: 124-140.
Korosoglou G, Schmidt A, Lichtenberg M, Torsello G, Grozinger G, Mustapha J, et al. Crossing algorithm for infrainguinal chronic total occlusions: An interdisciplinary expert opinion statement. JACC Cardiovasc Interv. 2023; 16: 317-331.
Goldman RE, Parker DR, Eaton CB, Borkan JM, Gramling R, Cover RT, et al. Patients' perceptions of cholesterol, cardiovascular disease risk, and risk communication strategies. Ann Fam Med. 2006; 4: 205-212.