[en] We report the fatal outcome of two patients infected by SARS-CoV-2 and exhibiting severe lung lesions at the thoracic imaging and autopsic examination. We also describe the biosecurity measures to adopt when performing autopsies during the Covid-19 pandemia.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
DELVENNE, Marie ; Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine - Pool assistants
de Froidmont, S; Service d'Anatomie pathologique, CHU Liège, Belgique.
Davenne, E; Service d'Anatomie pathologique, CHU Liège, Belgique.
Detrembleur, Nancy ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Oury, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Language :
French
Title :
Lésions pulmonaires dans la COVID-19 sévère : confrontation anatomoclinique.
Alternative titles :
[fr] Lung lesions in severe COVID-19 : anatomoclinical confrontation.
Publication date :
November 2020
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Be
Zhu N, Zhang D, Wang W, et al. A novel Coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727-33.
Fu Y. Understanding SARS-CoV-2-mediated inflammatory responses : from mechanisms to potential therapeutic tools. Virol Sin 2020;35:266-71.
Pan F, Ye T, Sun P, et al. Time course of lung changes on chest CT during recovery from 2019 novel Coronavirus (COVID-19) pneumonia. Radiology 2020;295:715-21.
https://prevent.be/fr/banque-de-connaissance/agents-biologiques- et-covid-19. Dernière consultation le 31 août 2020.
van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARSCoV- 1. N Engl J Med 2020;382:1564-7.
Chin AW, Chu JT, Perera MR, et al. Stability of SARSoV- 2 in different environmental conditions. Lancet Microbe 2020;1:e10.
Cascella M, Rajnik M, Cuomo A, et al. Features, evaluation and treatment Coronavirus (COVID-19). In : StatPearls. Treasure Island (FL) : StatPearls Publishing;2020.
Hanley B, Lucas SB, Youd E, et al. Autopsy in suspected COVID-19 cases. J Clin Pathol 2020;73:239-42.
https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidancepostmortem- specimens.html. Dernière consultation le 31 août 2020.
Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020;8:420-2.
Carsana L, Sonzogni A, Nasr A, et al. Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study. Lancet Infect Dis 2020;S1473- 3099:30434-5.
Calabrese F, Pezzuto F, Fortarezza F, et al. Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists. Virchows Arch 2020;477:359-72.
Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid- 19. N Engl J Med 2020;383:120-8.
Schaefer IM, Padera RF, Solomon IH, et al. In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19. Mod Pathol 2020;11:doi:10.1038/s41379-020-0595-z.
Barnes BJ, Adrover JM, Baxter-Stoltzfus A, et al. Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med 2020;217:e20200652.
Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet 2020;395:1417-8.
Tian S, Hu W, Niu L, et al. Pulmonary pathology of earlyphase 2019 novel Coronavirus (COVID-19) pneumonia in two patients with lung cancer. J Thorac Oncol 2020;15:700-4.
Peters P, Sprynger M, Lancellotti P, Oury C. Coagulopathies, risque thrombotique et anticoagulation dans la COVID-19. Rev Med Liege 2020;75 (Suppl):S86-S93.
Klok FA, Kruip MJ, van der Meer NJ, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 2020;191:145-7.
Cui S, Chen S, Li X, et al. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost 2020;18:1421-4.
Llitjos JF, Leclerc M, Chochois C, et al. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J Thromb Haemost 2020;18:1743-6.
Middeldorp S, Coppens M, van Haaps TF, et al. Incidence of venous thromboembolism in hospitalised patients with COVID-19. J Thromb Haemost 2020;18:1995-2002.
Helms J, Tacquard C, Severac F, et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection : a multicenter prospective cohort study. Intensive Care Med 2020;46:1089-98.
Wichmann D, Sperhake JP, Lütgehetmann M, et al. Autopsy findings and venous thromboembolism in patients with COVID-19. Ann Intern Med 2020;173:268-77.
Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and thrombotic or thromboembolic disease : implications for prevention, antithrombotic therapy, and follow-up: JACC state-ofthe- art review. J Am Coll Cardiol 2020;75:2950-73.
Leonard-Lorant I, Delabranche X, Severac F, et al. Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to D-dimer levels. Radiology 2020;296:E189-91.
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 2020;18:844-7.
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054-62.
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506.
Terpos E, Ntanasis-Stathopoulos I, Elalamy I, et al. Hematological findings and complications of COVID-19. Am J Hematol 2020;95:834-47.
Giusti B, Gori AM, Alessi M, et al. Sars-CoV-2 induced coagulopathy and prognosis in hospitalised patients : a snapshot from Italy. Thromb Haemost 2020;120:1233-6.
Laridan E, Martinod K, De Meyer SF. Neutrophil extracellular traps in arterial and venous thrombosis. Semin Thromb Hemost 2019;45:86-93.
Nicolai L, Leunig A, Brambs A, et al. Immunothrombotic dysregulation in COVID-19 pneumonia is associated with respiratory failure and coagulopathy. Circulation 2020;142:1176-89.
Radermecker C, Detrembleur N, Guiot J, et al. Neutrophil extracellular traps infiltrate the lung airway, interstitial and vascular compartments in severe Covid-19. J Exp Med 2020;217:e20201012.
Zuo Y, Yalavarthi S, Shi H, et al. Neutrophil extracellular traps in COVID-19. JCI Insight 2020;doi:10.1172/jci.insight.138999.
Tang N, Bai H, Chen X, et al. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 2020;18:1094-9.
Paranjpe I, Fuster V, Lala A, et al. Association of treatment dose anticoagulation with in-hospital survival among hospitalised patients with COVID-19. J Am Coll Cardiol 2020;76:122-4.
Spyropoulos AC, Levy JH, Ageno W, et al. Scientific and standardization committee communication: clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalised patients with COVID-19. J Thromb Haemost 2020;18:1859-65.
Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood 2020;135:2033-40.
Shang Y, Pan C, Yang X, et al. Management of critically ill patients with COVID-19 in ICU : statement from front-line intensive care experts in Wuhan, China. Ann Intensive Care 2020;10:73.
Bikdeli B, Madhavan MV, Gupta A, et al. Pharmacological agents targeting thromboinflammation in COVID-19 : review and implications for future research. Thromb Haemost 2020;120:1004-24.
Belgian clinical guidance on anticoagulation management in hospitalised and ambulatory patients with COVID-19. https://www.bsth.be/professionals. Dernière consultation le 31 août 2020.
Copin MC, Parmentier E, Duburcq T, et al. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med 2020;46:1124-6.