Unlocking the mysteries of milk oligosaccharides: Structure, metabolism, and function.

Animal milk; Application; Beneficial function; Human milk; Milk oligosaccharides (MOs); Oligosaccharides; Prebiotics; Infant, Newborn; Animals; Female; Humans; Oligosaccharides/chemistry; Infant Formula/chemistry; Prebiotics/analysis; Mammals/metabolism; Milk/chemistry; Milk, Human/chemistry; Complex carbohydrates; Human breast milks; Infant nutritions; Milk oligosaccharide; Oligosaccharide complexes; Oligosaccharide structure; Infant Formula; Mammals; Milk; Milk, Human; Organic Chemistry; Polymers and Plastics; Materials Chemistry

Résumé :

[en] Milk oligosaccharides (MOs), complex carbohydrates prevalent in human breast milk, play a vital role in infant nutrition. Serving as prebiotics, they inhibit pathogen adherence, modulate the immune system, and support newborn brain development. Notably, MOs demonstrate significant variations in concentration and composition, both across different species and within the same species. These characteristics of MOs lead to several compelling questions: (i) What distinct beneficial functions do MOs offer and how do the functions vary along with their structural differences? (ii) In what ways do MOs in human milk differ from those in other mammals, and what factors drive these unique profiles? (iii) What are the emerging applications of MOs, particularly in the context of their incorporation into infant formula? This review delves into the structural characteristics, quantification methods, and species-specific concentration differences of MOs. It highlights the critical role of human MOs in infant growth and their potential applications, providing substantial evidence to enhance infant health and development.

Disciplines :

Microbiologie

Auteur, co-auteur :

Yao, Qianqian; State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China, Department of Food Science, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

Gao, Yanan; State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China

Zheng, Nan; State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China

Delcenserie, Véronique ; Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Gestion de la qualité dans la chaîne alimentaire

Wang, Jiaqi; State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China. Electronic address: jiaqiwang@vip.163.com

Langue du document :

Anglais

Titre :

Unlocking the mysteries of milk oligosaccharides: Structure, metabolism, and function.

Date de publication/diffusion :

15 mai 2024

Titre du périodique :

Carbohydrate Polymers

ISSN :

0144-8617

eISSN :

1879-1344

Maison d'édition :

Elsevier, England

Volume/Tome :

332

Pagination :

121911

Peer reviewed :

Peer reviewed vérifié par ORBi

URL complémentaire :

https://api.elsevier.com/content/article/PII:S0144861724001371?httpAccept=text/xml

Subventionnement (détails) :

This study was supported by grants from the National Key R&D Program of China ( 2022YFD1600104 ), National Key R&D Program of China ( 2022YFD1600103 ), the Ministry of Modern Agro-Industry Technology Research System of China ( CARS-36 ).

Disponible sur ORBi :

depuis le 22 mai 2025

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