Impact of anthropometric factors on outcomes in atrial fibrillation patients: analysis on 10 220 patients from the European Society of Cardiology (ESC)-European Heart Rhythm Association (EHRA) EurObservational Research Programme on Atrial Fibrillation (EORP-AF) general long-term registry.
Boriani, Giuseppe; Vitolo, Marco; Malavasi, Vincenzo Let al.
2022 • In European Journal of Preventive Cardiology, 29 (15), p. 1967 - 1981
Atrial fibrillation; Body mass index; Lean body mass; Obesity; Outcome; Stroke; Humans; Male; Female; Infant; Risk Factors; Registries; Body Weight; Atrial Fibrillation/diagnosis; Atrial Fibrillation/epidemiology; Atrial Fibrillation/complications; Cardiology; Epidemiology; Cardiology and Cardiovascular Medicine
Abstract :
[en] [en] AIM: To investigate the association of anthropometric parameters [height, weight, body mass index (BMI), body surface area (BSA), and lean body mass (LBM)] with outcomes in atrial fibrillation (AF).
METHODS AND RESULTS: Ten-thousand two-hundred twenty patients were enrolled [40.3% females, median age 70 (62-77) years, followed for 728 (interquartile range 653-745) days]. Sex-specific tertiles were considered for the five anthropometric variables. At the end of follow-up, survival free from all-cause death was worse in the lowest tertiles for all the anthropometric variables analyzed. On multivariable Cox regression analysis, an independent association with all-cause death was found for the lowest vs. middle tertile when body weight (hazard ratio [HR] 1.66, 95%CI 1.23-2.23), BMI (HR 1.65, 95%CI 1.23-2.21), and BSA (HR 1.49, 95%CI 1.11-2.01) were analysed in female sex, as well as for body weight in male patients (HR 1.61, 95%CI 1.25-2.07). Conversely, the risk of MACE was lower for the highest tertile (vs. middle tertile) of BSA and LBM in males and for the highest tertile of weight and BSA in female patients. A higher occurrence of haemorrhagic events was found for female patients in the lowest tertile of height [odds ratio (OR) 1.90, 95%CI 1.23-2.94] and LBM (OR 2.13, 95%CI 1.40-3.26).
CONCLUSIONS: In AF patients height, weight, BMI, BSA, and LBM were associated with clinical outcomes, with all-cause death being higher for patients presenting lower values of these variables, i.e. in the lowest tertiles of distribution. The anthropometric variables independently associated with other outcomes were also different between male and female subjects.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Boriani, Giuseppe ; Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy
Vitolo, Marco; Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy ; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK ; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy
Malavasi, Vincenzo L; Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy
Proietti, Marco ; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK ; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy ; Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy
Fantecchi, Elisa; Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy
Diemberger, Igor ; Department of Experimental, Diagnostic and Specialty Medicine, Institute of Cardiology, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
Fauchier, Laurent ; Service de Cardiologie, Centre Hospitalier Universitaire Trousseau, Tours, France
Marin, Francisco; Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, University of Murcia, CIBERCV, Murcia, Spain
Nabauer, Michael ; Department of Cardiology, Ludwig-Maximilians-University, Munich, Germany
Potpara, Tatjana S; School of Medicine, University of Belgrade, Belgrade, Serbia ; Intensive Arrhythmia Care, Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia
Dan, Gheorghe-Andrei; 'Carol Davila' University of Medicine, Colentina University Hospital, Bucharest, Romania
Kalarus, Zbigniew; Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland
Tavazzi, Luigi; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
Maggioni, Aldo Pietro; ANMCO Research Center, Firenze, Italy
Lane, Deirdre A; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK ; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Lip, Gregory Y H; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK ; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
ESC-EHRA EORP-AF Long-Term General Registry Investigators
Sprynger, Muriel ; Université de Liège - ULiège > Département des sciences cliniques
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