[en] This study presents a sustainable and innovative approach to waste valorisation by isolating and characterising bioactive norursane-type triterpenoids from the solid waste of Rosmarinus tournefortii de Noé. A cost-effective, solvent-based recrystallisation method was developed as an eco-friendly alternative to traditional chromatography techniques, which are often expensive and resource-intensive. Individual triterpenoids were structurally characterised using ATR-FTIR, CHNSO elemental analysis, 1D and 2 D NMR, UHPLC-MS/MS, and stereochemical analysis with Schrödinger's Maestro software. Their bioactivities were extensively evaluated. Notably, compound 3' exhibited enhanced antimicrobial activity in its amorphous form compared to its crystalline counterpart, highlighting the influence of physical structure on bioactivity. In contrast, the crystalline form of the same compound showed enhanced tyrosinase inhibitory activity, indicating that different physical states may favour different biological functions. Furthermore, the isolated compounds also demonstrated significant skin depigmentation properties through tyrosinase inhibition, with compound 2 showing the most potent effect. Molecular docking supported this activity, revealing a higher binding affinity than kojic acid. Compound 1 showed promising antidiabetic potential by outperforming acarbose in docking studies with α-amylase and α-glucosidase. These findings highlight the potential of norursane triterpenoids as multifunctional bioactive agents. It is hypothesised that such compounds, derived from agro-industrial waste, hold significant promise for use in advanced food materials. The study proposes their integration into porous food packaging systems for controlled release and targeted bioactivity, with attention to their interactions within food matrices.
Disciplines :
Agriculture & agronomy Chemistry
Author, co-author :
Ziani, Imane ; Physical Chemistry of Natural Substances and Process Research Team, Laboratory of Applied Chemistry and Environment, Faculty of Sciences, Chemistry Department, Mohammed First University, Oujda, Morocco ; International Society of Engineering Science and Technology, Nottingham, United Kingdom
Bouakline, Hamza; Physical Chemistry of Natural Substances and Process Research Team, Laboratory of Applied Chemistry and Environment, Faculty of Sciences, Chemistry Department, Mohammed First University, Oujda, Morocco
Merzouki, Mohammed; Laboratory of Applied Chemistry and Environment, Faculty of Sciences, Chemistry Department, Mohammed First University, Oujda, Morocco
Fauconnier, Marie-Laure ; Université de Liège - ULiège > TERRA Research Centre > Chemistry for Sustainable Food and Environmental Systems (CSFES)
Sher, Farooq ; Department of Engineering, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
Bentouhami, Nour; Laboratory of Bio-Resources, Ethno-Pharmacology and Health, Faculty of Sciences, Mohammed First University, Biotechnology, Oujda, Morocco
Kadier, Abudukeremu; Xinjiang Key Laboratory of Separation Material and Technology, The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China ; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, China
Ansar, Sabah; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
Asehraou, Abdeslam; Laboratory of Bio-Resources, Ethno-Pharmacology and Health, Faculty of Sciences, Mohammed First University, Biotechnology, Oujda, Morocco
Challioui, Allal; Laboratory of Applied Chemistry and Environment, Faculty of Sciences, Chemistry Department, Mohammed First University, Oujda, Morocco
El Bachiri, Ali; Physical Chemistry of Natural Substances and Process Research Team, Laboratory of Applied Chemistry and Environment, Faculty of Sciences, Chemistry Department, Mohammed First University, Oujda, Morocco
Language :
English
Title :
Exploring bioactive compounds from rosemary waste for structural insights and food packaging innovation
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