[en] Bovine serum albumin (BSA) hydrogels are non-immunogenic, low-cost, biocompatible, and biodegradable. In order to avoid toxic cross-linking agents, gellan was oxidized with NaIO4 to obtain new functional groups like dialdehydes for protein-based hydrogel cross-linking. The formed dialdehyde groups were highlighted with FT-IR and NMR spectroscopy. This paper aims to investigate hydrogel films for biomedical applications obtained by cross-linking BSA with oxidized gellan (OxG) containing immobilized β-cyclodextrin-curcumin inclusion complex (β-CD-Curc) The β-CD-Curc improved the bioavailability and solubility of Curc and was prepared at a molar ratio of 2:1. The film's structure and morphology were evaluated using FT-IR spectroscopy and SEM. The swelling degree (Q%) values of hydrogel films depend on hydrophilicity and pH, with higher values at pH = 7.4. Additionally, the conversion index of -NH2 groups into Schiff bases increases with an increase in OxG amount. The polymeric matrix provides protection for Curc, is non-cytotoxic, and enhances antioxidant activity. At pH = 5.5, the skin permeability and release efficiency of encapsulated curcumin were higher than at pH = 7.4 because of the interaction of free aldehyde and carboxylic groups from hydrogels with amine groups from proteins present in the skin membrane, resulting in a better film adhesion and more efficient curcumin release.
Disciplines :
Chemistry
Author, co-author :
Tincu Iurciuc, Camelia Elena; Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Protection of the Environment, "Gheorghe Asachi" Technical University, 73 Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania ; Department of Pharmaceutical Technology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Daraba, Oana Maria; Faculty of Dental Medicine, "Apollonia" University, 11 Pacurari Street, 700355 Iasi, Romania
Jérôme, Christine ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie des macromolécules et des matériaux organiques (CERM)
Popa, Marcel ; Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Protection of the Environment, "Gheorghe Asachi" Technical University, 73 Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania ; Faculty of Dental Medicine, "Apollonia" University, 11 Pacurari Street, 700355 Iasi, Romania ; Academy of Romanian Scientists, 3 Ilfov Street, Sector 5, 050044 Bucureşti, Romania
Ochiuz, Lăcrămioara ; Department of Pharmaceutical Technology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Language :
English
Title :
Albumin-Based Hydrogel Films Covalently Cross-Linked with Oxidized Gellan with Encapsulated Curcumin for Biomedical Applications.
Authors are thankful for funding this work by a grant of the Ministry of Research, Innovation, and Digitization, from Romania, CNCS-UEFISCDI, project number: PN-III-P1-1.1-PD-2021-0553, within PNCDI III (PD61/2022).
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